Evolution of the Isd11-IscS complex reveals a single alpha-proteobacterial endosymbiosis for all eukaryotes

Molecular Biology and Evolution
Thomas A Richards, Mark van der Giezen

Abstract

Giardia and Trichomonas are eukaryotes without standard mitochondria but contain mitochondrial-type alpha-proteobacterium-derived iron-sulfur cluster (ISC) assembly proteins, located to mitosomes in Giardia and hydrogenosomes in Trichomonas. Although these data suggest a single common endosymbiotic ancestry for mitochondria, mitosomes, and hydrogenosomes, separate origins are still being proposed. Here, we present a bioinformatic analysis of Isd11, a recently described essential component of the mitochondrial ISC assembly pathway. Isd11 is unique to eukaryotes but functions closely with the alpha-proteobacterium-derived cysteine desulfurase IscS. We demonstrate the presence of homologues of Isd11 in all 5 eukaryotic supergroups sampled, including hydrogenosomal and mitosomal lineages. The eukaryotic invention of Isd11 as a functional partner to IscS directly implies a single shared alpha-proteobacterial endosymbiotic ancestry for all eukaryotes. This pinpoints the alpha-proteobacterial endosymbiosis to before the last common ancestor of all eukaryotes without ambiguity.

References

Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·A J RogerM L Sogin
Mar 24, 1998·Nature·W Martin, M Müller
Jun 22, 2000·Journal of Molecular Biology·L A KelleyM J Sternberg
Dec 26, 2001·Bioinformatics·H Shimodaira, M Hasegawa
Jul 6, 2002·Science·Alexandra Stechmann, Thomas Cavalier-Smith
Jun 19, 2003·Protist·Thomas A RichardsT Martin Embley
Dec 6, 2003·International Journal of Systematic and Evolutionary Microbiology·Alastair G B Simpson
Apr 10, 2004·Science·Sabrina D DyallPatricia J Johnson
Sep 3, 2004·Current Biology : CB·Alastair G B Simpson, Andrew J Roger
Sep 10, 2004·Molecular Biology and Evolution·Jan O AnderssonAndrew J Roger
Jan 25, 2005·Trends in Parasitology·Fiona L HenriquezCraig W Roberts
Mar 9, 2005·Trends in Biochemical Sciences·Roland Lill, Ulrich Mühlenhoff
Jun 9, 2005·EMBO Reports·Mark van der Giezen, Jorge Tovar
Jul 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Pavel DolezalJan Tachezy
Jul 30, 2005·Current Biology : CB·Naiara Rodríguez-EzpeletaB Franz Lang
Aug 27, 2005·Nature·Thomas A Richards, Thomas Cavalier-Smith
Mar 31, 2006·Nature·T Martin Embley, William Martin

❮ Previous
Next ❯

Citations

Jun 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Anastasios D TsaousisAndrew J Roger
May 6, 2010·The Journal of Biological Chemistry·Zdenek ParisJulius Lukes
Sep 13, 2011·The Journal of Biological Chemistry·Alok PandeyDebkumar Pain
Mar 28, 2008·Annual Review of Biochemistry·Roland Lill, Ulrich Mühlenhoff
Jun 2, 2007·Gene·Serge N VinogradovJacques R Vanfleteren
Jun 17, 2009·The Journal of Eukaryotic Microbiology·Mark van der Giezen
Sep 26, 2013·Biochemical Society Transactions·Heike Angerer
Jul 31, 2013·Critical Reviews in Biochemistry and Molecular Biology·V Lila KoumandouMark C Field
Apr 19, 2012·Molecular Plant·Valeria R TurowskiDiego F Gomez-Casati
May 23, 2015·PLoS Genetics·Béatrice RocheBéatrice Py
May 23, 2015·PLoS Genetics·Heeyong YoonAndrew Dancis
May 23, 2012·Biochimica Et Biophysica Acta·Roland LillUlrich Mühlenhoff
Sep 21, 2013·Biochemical and Biophysical Research Communications·Kerem TeraliMark van der Giezen
Apr 7, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Priscila Peña-Diaz, Julius Lukeš
Sep 25, 2008·Journal of Bioenergetics and Biomembranes·Michael W Mather, Akhil B Vaidya
Jan 13, 2011·Chemistry : a European Journal·Swati Rawat, Timothy L Stemmler
Sep 13, 2020·Plants·Alejandro M ArmasDiego F Gomez-Casati
Jan 27, 2021·Plants·Diego F Gomez-CasatiAgustina Terenzi
Oct 12, 2007·Chemical Reviews·Paulette M Vignais, Bernard Billoud
Oct 31, 2019·Biochemistry·María Georgina HerreraJavier Santos
Nov 15, 2011·International Journal for Parasitology·Rachel E SchneiderPatricia J Johnson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.