Evolution of the mdx mouse cardiomyopathy: physiological and morphological findings

Neuromuscular Disorders : NMD
John G QuinlanLinda S Levin

Abstract

Heart failure is a major cause of death in boys with Duchenne muscular dystrophy. In order to determine if the cardiac function of the mdx mouse is similarly disturbed, we performed murine echocardiograms and left heart catheterization studies, along with morphometric analysis of cardiac fibrosis. Serial echocardiograms in mdx mice revealed the evolution from normal cardiac function in young mice to a dilated cardiomyopathy in adult mice. Very old mdx mice exhibited a widespread but patchy increase in ventricular wall fibrosis. These results show that the mdx cardiac function is more impaired than was previously thought and shares important clinical features with the cardiomyopathy of Duchenne muscular dystrophy.

References

Nov 1, 1979·Japanese Circulation Journal·H TanakaH Katanasako
Feb 11, 1977·Human Genetics·G A DanieliC Angelini
Oct 1, 1992·Statistics in Medicine·S L Zeger, K Y Liang
Mar 1, 1990·International Journal of Cardiology·G NigroR J Bain
May 1, 1983·Muscle & Nerve·G NigroS Stefanelli
Oct 1, 1982·Neurology·S J GoldbergL M Valdes-Cruz
May 1, 1995·The Anatomical Record·J P LefaucheurA Sebille
Oct 1, 1996·Neuromuscular Disorders : NMD·P MelaciniS Dalla Volta
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·L A MegeneyM A Rudnicki
Sep 1, 2000·Journal of Molecular and Cellular Cardiology·S Lu, A Hoey
Feb 13, 2001·The Journal of Clinical Investigation·R D CohnK P Campbell
May 30, 2001·Cardiovascular Research·Y KamogawaC Tei
Feb 18, 2003·Cardiology·Josef Finsterer, Claudia Stöllberger

❮ Previous
Next ❯

Citations

Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Josef Finsterer, Claudia Stöllberger
Apr 24, 2009·Pflügers Archiv : European journal of physiology·Vyacheslav M ShkrylNatalia Shirokova
Nov 13, 2009·Bulletin of Experimental Biology and Medicine·L I KrivovN V Komarova
Oct 18, 2007·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Dorothy M BrancoCharles I Berul
Aug 4, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Brian BostickDongsheng Duan
Apr 7, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Masatoshi IshizakiMakoto Uchino
Nov 21, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mingxing WangQilong Lu
Sep 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bo WuQi Long Lu
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Satyam SarmaXander H T Wehrens
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Candace M AdamoJoseph A Beavo
Oct 10, 2009·Cardiovascular Research·Natee JearawiriyapaisarnMonte S Willis
Sep 22, 2006·Human Molecular Genetics·Dongsheng Duan
Nov 11, 2010·Human Molecular Genetics·Alastair CrispMatthew J A Wood
Jul 30, 2010·Science Translational Medicine·Kumaran ChandrasekharanPaul T Martin
Sep 29, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Nina D UllrichErnst Niggli
May 18, 2011·BMC Cardiovascular Disorders·Christopher F SpurneyKanneboyina Nagaraju
Oct 24, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Wei LiXin Yu
Jan 18, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Elizabeth GreallyGuy A MacGowan
Nov 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Dariusz NowakWladimir Bozilow
Apr 29, 2014·BioMed Research International·Ashling Holland, Kay Ohlendieck
Dec 20, 2013·Stem Cells and Development·Lien-Cheng HsiaoCarolyn A Carr
Jun 28, 2014·Proceedings of the National Academy of Sciences of the United States of America·Helena M ViolaLivia C Hool
Jul 28, 2010·The Journal of General Physiology·Benjamin L ProsserW J Lederer
Sep 23, 2009·Journal of Molecular and Cellular Cardiology·Yan BurelleChristine Des Rosiers
Mar 25, 2009·Pharmacology & Therapeutics·Emily J Tsai, David A Kass
Feb 17, 2009·Neuromuscular Disorders : NMD·Raffaella WillmannMarkus A Ruegg
Nov 12, 2015·Journal of Molecular and Cellular Cardiology·Qiongling WangXander H T Wehrens
Oct 22, 2008·Journal of Molecular and Cellular Cardiology·Wen ZhangKieran Clarke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.