PMID: 9529070Apr 7, 1998Paper

Evolution of the primary immune response to Histoplasma capsulatum in murine lung

Infection and Immunity
J A Cain, George S Deepe

Abstract

Histoplasma capsulatum induces a cell-mediated immune response in the lungs and lymphoid organs of mammals. In this study, we analyzed the progression of the cytokine and inflammatory reactions in the lungs of mice infected intranasally with H. capsulatum. We measured cytokine mRNA levels and determined the inflammatory cell populations during the active phase of infection (<3 weeks). Transcription of genes encoding interleukin-2 (IL-2), IL-4, and IL-12 and gamma interferon (IFN-gamma) was detectable as early as day 3 of infection, whereas a signal for IL-10 was never observed. Competitive PCR analysis demonstrated that enhanced expression of IL-12 mRNA was observed by day 3 and that expression of mRNA for IL-2 and IFN-gamma progressively increased from day 5 to day 10. All levels declined by day 14. Analysis of the inflammatory response revealed an initial elevation in myeloid cells (Mac-1+) and natural killer (NK) cells followed by a rise in T cells, predominantly CD4+ cells. Since IFN-gamma is a key factor in host defense, we performed cytoplasmic staining to determine the cell populations that produced this cytokine. The hierarchy of synthesis was CD4+ > CD8+ > NK cells. Thus, H. capsulatum provokes an orderly modulation of...Continue Reading

References

Jan 1, 1976·Journal of Immunological Methods·J W Goding
Jul 1, 1988·Infection and Immunity·A M GomezG S Deepe
Jun 1, 1995·Current Opinion in Immunology·T M Doherty
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R A SederW E Paul
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R T GazzinelliA Sher
Nov 1, 1993·Infection and Immunity·M F FojtasekC T Schnizlein-Bick
Sep 27, 1993·Journal of Immunological Methods·S L ReinerR M Locksley

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Citations

Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·F J GomezG S Deepe
Oct 17, 2003·The Journal of Clinical Investigation·Joshua D NosanchukArturo Casadevall
Jun 19, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·George S Deepe
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·George S Deepe, Reta S Gibbons
Dec 23, 2008·American Journal of Respiratory Cell and Molecular Biology·Rina TakamiyaMark A Perrella
Nov 28, 2012·Medical Mycology·Chadi A HageL Joseph Wheat
Jun 11, 2020·Biomolecules·Morgana K B PradoLúcia H Faccioli
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lance F BartonJohn J Monaco
Jul 15, 2003·The Journal of Biological Chemistry·Francis X McCormackGeorge S Deepe
Jun 26, 2008·Journal of Leukocyte Biology·George S DeepeA George Smulian
Dec 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jacob A MayfieldJasper Rine
Mar 4, 2020·Journal of Fungi·Camila BonicheCarlos Pelleschi Taborda
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R Allendoerfer, G S Deepe
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·George S Deepe, Reta S Gibbons
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lance F BartonJohn J Monaco
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eszter Lázár-MolnárJoshua D Nosanchuk
Jun 24, 2003·Infection and Immunity·Lucy A GildeaGeorge S Deepe
Nov 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·George S Deepe, William R Buesing
Jul 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wendy A Szymczak, George S Deepe
Nov 21, 2007·Medical Mycology·Javier CapillaDavid A Stevens
Mar 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danielle N Kroetz, George S Deepe
Jun 9, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roger A FecherGeorge S Deepe
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Holly L Allen, George S Deepe
Jan 25, 2012·The Journal of Infectious Diseases·Danielle N Kroetz, George S Deepe
Nov 13, 2008·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Louise C AllenGary F McCracken
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B A Wu-HsiehR Ahmed
Jan 31, 2009·Infection and Immunity·Allan J GuimarãesJoshua D Nosanchuk
Aug 28, 1998·Research in Immunology·G S Deepe, R A Seder
Jul 5, 2003·Journal of Microbiological Methods·Irma A J M Bakker-Woudenberg

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