Evolution of the protease-activated receptor family in vertebrates

International Journal of Molecular Medicine
Min JinJi-Fu Wei

Abstract

Belonging to the G protein-coupled receptor (GPcr) family, the protease-activated receptors (Pars) consist of 4 members, PAR1-4. PARs mediate the activation of cells via thrombin, serine and other proteases. Such protease-triggered signaling events are thought to be critical for hemostasis, thrombosis and other normal pathological processes. In the present study, we examined the evolution of PARs by analyzing phylogenetic trees, chromosome location, selective pressure and functional divergence based on the 169 functional gene alignment sequences from 57 vertebrate gene sequences. We found that the 4 Pars originated from 4 invertebrate ancestors by phylogenetic trees analysis. The selective pressure results revealed that only PAR1 appeared by positive selection during its evolution, while the other PAR members did not. In addition, we noticed that although these PARs evolved separately, the results of functional divergence indicated that their evolutional rates were similar and their functions did not significantly diverge. The findings of our study provide valuable insight into the evolutionary history of the vertebrate PAR family.

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Citations

Jul 6, 2016·Frontiers in Genetics·Rebecca A RoseroMenashe Bar-Eli
Nov 23, 2017·Frontiers in Genetics·Suzie Chen

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Software Mentioned

PAML4
MrBayes
BLAST
CodeML
Ensembl
MEGA
tBLASTn
Diverge
Clustal
PAML

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