PMID: 9162093Jan 1, 1997Paper

Evolution of the proteasome components

Immunogenetics
A L Hughes

Abstract

A phylogenetic analysis of proteasome subunits revealed two major families (alpha and beta) which originated by an ancient gene duplication prior to the divergence of archaebacteria and eukaryotes. Numerous gene duplications have subsequently occurred in eukaryotes; at least nine of these duplications were shown to have occurred prior to the divergence of animals and fungi. In mammals, two genes encoding proteasome subunits (LMP2 and LMP7) are located in the major histocompatibility complex (MHC) region and play a specific role in generation of peptides for presentation by class I MHC molecules. Phylogenetic analysis of LMP7 and related sequences from mammals and lower vertebrates indicated that this locus arose by gene duplication prior to the divergence of jawed and jawless vertebrates; the time of this duplication was estimated to have been about 600 million years ago. The evolutionary history of the proteasome subunits provides support for a model of the evolution of new gene function postulating that, after gene duplication, the proteins encoded by daughter loci can adapt to specialized functions previously performed by the product of a single generalized ancestral locus.

Citations

Sep 23, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A L Hughes, M Yeager
Oct 6, 2006·Journal of Molecular Evolution·Mario X Ruiz-González, Ignacio Marín
Mar 23, 2006·Immunogenetics·Larry J DishawCharles H Bigger
Aug 1, 1998·Trends in Ecology & Evolution·S V Edwards, P W Hedrick
Dec 7, 2011·Molecular Biology and Evolution·Michael Lynch
Aug 18, 2005·Nucleic Acids Research·Kira S MakarovaEugene V Koonin
May 24, 2001·Molecular Biology and Evolution·K Wollenberg, J C Swaffield
Feb 3, 1999·Annual Review of Genetics·A L Hughes, M Yeager
Jul 16, 2011·Annual Review of Genomics and Human Genetics·Michael LynchMina Rho
Feb 22, 2003·Journal of Molecular Biology·Christoph GilleCornelius Frömmel
Jul 19, 2008·IUBMB Life·Tobias Jung, Tilman Grune
Dec 2, 2004·Developmental and Comparative Immunology·David H Bos, David Posada
Jun 2, 2007·DNA Sequence : the Journal of DNA Sequencing and Mapping·Yang LiuQin Zhang
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuko OhtaMartin F Flajnik
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M S ClarkG Elgar

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