Evolution of the rate of biological aging using a phenotype based computational model

Journal of Theoretical Biology
Aristotelis Kittas

Abstract

In this work I introduce a simple model to study how natural selection acts upon aging, which focuses on the viability of each individual. It is able to reproduce the Gompertz law of mortality and can make predictions about the relation between the level of mutation rates (beneficial/deleterious/neutral), age at reproductive maturity and the degree of biological aging. With no mutations, a population with low age at reproductive maturity R stabilizes at higher density values, while with mutations it reaches its maximum density, because even for large pre-reproductive periods each individual evolves to survive to maturity. Species with very short pre-reproductive periods can only tolerate a small number of detrimental mutations. The probabilities of detrimental (P(d)) or beneficial (P(b)) mutations are demonstrated to greatly affect the process. High absolute values produce peaks in the viability of the population over time. Mutations combined with low selection pressure move the system towards weaker phenotypes. For low values in the ratio P(d)/P(b), the speed at which aging occurs is almost independent of R, while higher values favor significantly species with high R. The value of R is critical to whether the population surviv...Continue Reading

References

Sep 21, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·T B Kirkwood, R Holliday
Nov 24, 1977·Nature·T B Kirkwood
Apr 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T B Kirkwood, M R Rose
Aug 1, 1990·Biological Reviews of the Cambridge Philosophical Society·Z A Medvedev
Sep 1, 1966·Journal of Theoretical Biology·W D Hamilton
Jun 6, 1998·Experimental Gerontology·D E Martínez
Oct 1, 1995·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·T J PennaD Stauffer
Apr 11, 2001·Experimental Gerontology·L Partridge
Nov 3, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·N G de Medeiros, R N Onody
Sep 26, 2002·Journal of the Royal Statistical Society. Series A, (Statistics in Society)·A R Thatcher
Apr 12, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A O SousaJ S Sá Martins
Jul 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ronald D Lee
May 12, 2004·Theoretical Population Biology·James W VaupelJutta Gampe
Dec 22, 2004·Mechanisms of Ageing and Development·Fotios Drenos, Thomas B L Kirkwood
Jan 25, 2005·Mechanisms of Ageing and Development·Armand M LeroiBas Zwaan
Mar 1, 2005·Cell·Thomas B L Kirkwood
Oct 26, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·J B Coe, Y Mao
Feb 14, 2006·The American Naturalist·Marc Mangel, Stephan B Munch
Jan 19, 2008·Theory in Biosciences = Theorie in Den Biowissenschaften·Stanisław Cebrat, Dietrich Stauffer

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Citations

Jul 23, 2013·Ageing Research Reviews·Eva BrutovskáKarol Mičieta

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