Evolution of the urinary proteome during human renal development and maturation: variations with gestational and postnatal age

Pediatric Research
Jennifer R CharltonRobert L Chevalier

Abstract

Low birth weight is associated with deficits in nephron number in the infant kidney and increased risk of adulthood hypertension and renal dysfunction. Urinary biomarkers may be potential indicators of renal reserve, but little is known about the influence of gestational and postnatal age on the expression of urinary proteins. The aims of this study were to determine the relationships between selected urinary proteins and renal maturation. We hypothesized that urinary protein patterns would change over time during late nephrogenesis and renal maturation. Urine samples were collected at birth and over 12 mo from preterm (33-35 wk) and term (38-40 wk) infants. Candidate urinary proteins were identified by antibody array and quantified with enzyme-linked immunosorbent assay. Preterm infants at birth were found to have relatively elevated levels of insulin-like growth factor binding protein-1, -2, and -6, monocyte chemotactic protein-1, CD14, and sialic acid-binding Ig-like lectin 5. These markers gradually decline to levels similar to those of full-term infants by 2-6 mo of life. In contrast, many urinary markers in healthy full-term infants remain stable over the first year of life. Gestational and postnatal age must be considere...Continue Reading

References

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Citations

Feb 11, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marissa J DeFreitasCarolyn L Abitbol
Aug 26, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Leon A Bach, Lorna J Hale
Oct 26, 2016·Journal of Proteomics·Natalia L StarodubtsevaGennady T Sukhikh
May 20, 2017·Clinical Proteomics·Young Wook ChoiSang-Ho Lee
Jul 9, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Douglas G Matsell, Marisa Catapang

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