Evolution of the variable gene segments and recombination signal sequences of the human T-cell receptor alpha/delta locus

Immunogenetics
Marsha R Haynes, Gillian E Wu

Abstract

The T-cell receptor (TCR) alpha and delta loci are particularly interesting because of their unique genomic structure, in that the gene segments for each locus are interspersed. The origin of this remarkable gene segment arrangement is obscure. In this report, we investigated the evolution of the TCRalpha and delta variable loci and their respective recombination signal sequences (RSSs). Our phylogenetic analyses divided the alpha and delta variable gene segments into two major groups each with distinguishing motifs in both the framework and complementarity determining regions (CDRs). Sequence analyses revealed that TCRdelta variable segments share similar CDR2 sequences with immunoglobulin light chain variable segments, possibly revealing similar evolutionary histories. Maximum likelihood analysis of the region on Chromosome 14q11.2 containing the loci revealed two possible ancestral TCR alpha/delta variable segments, TRDV2 and TRAV1-1/ 1-2, respectively. Maximum parsimony revealed different evolutionary patterns between the variable segment and RSS of the same variable gene arguing for dissimilar evolutionary origins. Two models could account for this difference: a V(D)J recombination activity involving embedded heptamer-like...Continue Reading

References

Dec 1, 1990·Biopolymers·R E Bruccoleri, M Karplus
Jul 1, 1989·Genes & Development·J E HesseM Gellert
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A J KormanD H Raulet
Dec 23, 1988·Cell·S M LewisM Gellert
Mar 25, 1988·JAMA : the Journal of the American Medical Association·S Tonegawa
Jan 1, 1985·Journal of Molecular Evolution·M HasegawaT Yano
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·S TonegawaA Bernardini
Apr 14, 1983·Nature·S Tonegawa
Jan 1, 1981·Journal of Molecular Evolution·J Felsenstein
May 25, 1994·Nucleic Acids Research·D A RamsdenG E Wu
Sep 1, 1993·Protein Science : a Publication of the Protein Society·V ColluraJ Garnier
Oct 1, 1995·Current Biology : CB·Y H Chien, R Jores
Jan 1, 1995·Immunogenetics·B ArdenT W Mak
Jan 1, 1995·Immunogenetics·B ArdenT W Mak
Jun 1, 1997·Current Opinion in Structural Biology·L Duret, P Bucher
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·M NeiT Sitnikova
Apr 9, 1998·International Immunology·L FanningG E Wu
Sep 4, 1998·Cell·D B Roth, N L Craig
Jan 14, 1999·International Immunology·M C VerschurenJ J van Dongen
Nov 5, 1999·Genetics·J Zhang, T Peterson
Feb 10, 2000·Molecular Biology and Evolution·M H Richards, J L Nelson
May 16, 2000·Experimental and Clinical Immunogenetics·D Scaviner, M P Lefranc
May 17, 2000·The Journal of Experimental Medicine·S M Lewis, G E Wu
Jul 25, 2000·Journal of Molecular Biology·O MichielinM Karplus
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·A HassaninG E Wu
Oct 10, 2001·European Journal of Immunology·R GolubG E Wu
Jan 10, 2003·Nucleic Acids Research·Marie-Paule Lefranc
May 3, 2003·Annals of the New York Academy of Sciences·Zhixin ZhangMax D Cooper
Jul 23, 2003·Immunity·Zhixin ZhangMax D Cooper
Apr 23, 2008·Current Protocols in Bioinformatics·James C Wilgenbusch, David Swofford
Jul 1, 1985·Evolution; International Journal of Organic Evolution·Joseph Felsenstein

❮ Previous
Next ❯

Citations

Dec 14, 2006·Immunogenetics·Marsha R Haynes, Gillian E Wu
May 5, 2009·Nature Genetics·Joachim HallmayerEmmanuel Mignot
Oct 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbera van SchaikIldiko Van Rhijn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.