Evolution of the vertebrate ABC gene family: analysis of gene birth and death

Genomics
Tarmo AnniloM Dean

Abstract

Vertebrate evolution has been largely driven by the duplication of genes that allow for the acquisition of new functions. The ATP-binding cassette (ABC) proteins constitute a large and functionally diverse family of membrane transporters. The members of this multigene family are found in all cellular organisms, most often engaged in the translocation of a wide variety of substrates across lipid membranes. Because of the diverse function of these genes, their large size, and the large number of orthologs, ABC genes represent an excellent tool to study gene family evolution. We have identified ABC proteins from the sea squirt (Ciona intestinalis), zebrafish (Danio rerio), and chicken (Gallus gallus) and, using phylogenetic analysis, identified those genes with a one-to-one orthologous relationship to human ABC proteins. All ABC protein subfamilies found in Ciona and zebrafish correspond to the human subfamilies, with the exception of a single ABCH subfamily gene found only in zebrafish. Multiple gene duplication and deletion events were identified in different lineages, indicating an ongoing process of gene evolution. As many ABC genes are involved in human genetic diseases, and important drug transport phenotypes, the understand...Continue Reading

References

Dec 22, 1999·Seminars in Cell & Developmental Biology·S Ohno
Oct 4, 2000·Nature Genetics·A Nasevicius, S C Ekker
Dec 26, 2001·Bioinformatics·S KumarM Nei
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Jun 5, 2002·Frontiers in Bioscience : a Journal and Virtual Library·William T PenberthyShuo Lin
Jul 27, 2002·Science·Samuel AparicioSydney Brenner
Jan 18, 2003·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Tarmo AnniloMichael Dean
Mar 1, 2003·Nature Genetics·Kathryn V Anderson, Philip W Ingham
Aug 14, 2003·Human Molecular Genetics·Caroline LefévreJudith Fischer
Sep 10, 2003·The Journal of Biological Chemistry·Natasha Y FrankMarkus H Frank
Mar 27, 2004·The New England Journal of Medicine·Sergey ShuleninMichael Dean
Jun 1, 2004·Journal of Bioenergetics and Biomembranes·Sonja-Verena AlbersArnold J Driessen
Jun 1, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Zhang-qun ChenMichael Dean
Jul 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Adam AmsterdamNancy Hopkins
Jul 28, 2004·The Journal of Biological Chemistry·Jinsheng DongAlan G Hinnebusch
Oct 22, 2004·Nature·UNKNOWN International Human Genome Sequencing Consortium
Mar 10, 2005·American Journal of Human Genetics·David P KelsellEdel A O'Toole
Aug 30, 2005·Annual Review of Genomics and Human Genetics·Michael Dean, Tarmo Annilo
Nov 16, 2005·Annual Review of Genetics·Masatoshi Nei, Alejandro P Rooney
Jan 20, 2006·The Journal of Biological Chemistry·Zhang-Qun ChenMichael Dean

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Citations

Mar 12, 2013·Parasitology International·Robert M Greenberg
Oct 18, 2012·Annual Review of Pharmacology and Toxicology·Satish CheepalaJohn D Schuetz
Dec 18, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Robert M Greenberg
Apr 23, 2009·BMC Genomics·Armin SturmMichael Dean
Oct 17, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·David J ThomasH Rex Gaskins
Sep 16, 2008·Molecular Biology and Evolution·Orsolya SymmonsTamás Arányi
Jul 1, 2010·Arhiv za higijenu rada i toksikologiju·Roberta Sauerborn KlobucarTvrtko Smital
Feb 19, 2009·Journal of Mammary Gland Biology and Neoplasia·Michael Dean
Sep 29, 2011·Drug Metabolism and Drug Interactions·Karobi MoitraMichael Dean
May 9, 2012·Environmental Science & Technology·Jenna CorcoranCharles R Tyler
Jan 5, 2011·Biological Chemistry·Karobi Moitra, Michael Dean
Jan 22, 2010·Journal of Cellular Biochemistry·Katarzyna A LechwardSusanne Falkner
Jan 25, 2016·The Science of the Total Environment·Susanne KeiterTill Luckenbach
Aug 19, 2015·Aquatic Toxicology·Denise KurthTill Luckenbach
Dec 3, 2014·Developmental Biology·Edward Roshan MirandaGad Shaulsky
Oct 20, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Margaret O James
Sep 28, 2010·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yong LongZongbin Cui
Nov 4, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jovica LoncarTvrtko Smital
Nov 21, 2009·Marine Environmental Research·Marta PopovicTvrtko Smital
Aug 8, 2009·Molecular and Cellular Neurosciences·Jun-Ping LiuHe Li
Jan 13, 2009·Advanced Drug Delivery Reviews·Robert W RobeySusan E Bates
Jul 3, 2010·The Journal of Investigative Dermatology·Qiaoli LiJouni Uitto
Aug 9, 2015·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Allison M ChurcherAdelino V M Canário
Aug 12, 2014·Congenital Anomalies·Yuhei NishimuraToshio Tanaka
Jul 2, 2015·Systematic Biology·Ikram UllahJens Lagergren
Oct 5, 2011·Essays in Biochemistry·Elie Dassa
Jun 29, 2010·The Biochemical Journal·Maarit Hölttä-VuoriElina Ikonen
Jan 10, 2012·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Joana CostaMarta Ferreira

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