Evolution of topical NSAIDs in the guidelines for treatment of osteoarthritis in elderly patients.

Drugs & Aging
Paul M Arnstein

Abstract

Increasing age is the primary predictor of osteoarthritis, the most prevalent painful condition in the US. Because there are no disease-modifying therapies for osteoarthritis, relief of symptoms and maintenance of quality of life through improving joint function become the focus of management. Although highly effective for pain relief, oral nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with systemic adverse reactions that are sometimes treatment limiting, especially for older patients. Thus, osteoarthritis management in elderly populations is shifting away from traditional NSAIDs to therapies that provide comparable pain relief with improved safety. Since the approval by the US Food and Drug Administration of the use of topical NSAIDs to manage osteoarthritis pain, current treatment guidelines put forth by several professional societies have begun to recommend topical NSAIDs as an alternative therapy and, most recently, as first-line therapy for osteoarthritis management in the elderly. This review provides an overview of the various treatment guidelines that are available to assist prescribers in making safe and effective decisions in the treatment of osteoarthritis in this high-risk patient population.

References

Jul 1, 1992·American Journal of Public Health·B H AlexanderM E Wolf
Aug 15, 1998·Arthritis and Rheumatism·D T Felson, Y Zhang
Jan 27, 1999·Journal of the American Geriatrics Society·R M LeipzigM E Tinetti
Nov 23, 2000·The New England Journal of Medicine·C BombardierUNKNOWN VIGOR Study Group
Aug 9, 2001·Archives of Physical Medicine and Rehabilitation·J M HausdorffH K Edelberg
Dec 3, 2003·Annals of the Rheumatic Diseases·K M JordanUNKNOWN Standing Committee for International Clinical Studies Including Therapeutic Trials ESCISIT
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Feb 17, 2005·The New England Journal of Medicine·Robert S BresalierUNKNOWN Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators
Feb 17, 2005·The New England Journal of Medicine·Scott D SolomonUNKNOWN Adenoma Prevention with Celecoxib (APC) Study Investigators
Jun 23, 2005·The Journal of the British Menopause Society·Hilary Wynne
Oct 20, 2005·Occupational and Environmental Medicine·M RossignolP Hilliquin
Nov 24, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Paul C WalkerUjjaini Khanderia
Aug 19, 2006·Journal of Gerontological Nursing·Ulf Jakobsson, Ingalill Rahm Hallberg
Sep 30, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Francis K L Chan
Mar 17, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Peter A ChykaUNKNOWN Healthcare Systems Bureau, Health Resources and Sevices Administration, Department of Health and Human Services
Apr 17, 2007·International Review of Neurobiology·Emilio Perucca
May 10, 2007·International Journal of Clinical Practice·S J PanchalJ I Wurzelmann
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sabita RoyJosephine Martin
Dec 20, 2007·Clinical Nurse Specialist CNS·Patricia O'Malley
Jan 1, 2008·Arthritis and Rheumatism·Reva C LawrenceUNKNOWN National Arthritis Data Workgroup
Feb 6, 2009·Drugs·Marco Lazzaroni, Gabriele Bianchi Porro
May 2, 2009·The American Journal of Cardiology·Michael E Farkouh, Bruce P Greenberg
Jul 4, 2009·Journal of the American Geriatrics Society·UNKNOWN American Geriatrics Society Panel on Pharmacological Management of Persistent Pain in Older Persons
Dec 17, 2009·Anesthesiology·Albert DahanTerry W Smith
Jun 5, 2010·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Paul Arnstein
Dec 15, 2010·Archives of Internal Medicine·Daniel H SolomonSebastian Schneeweiss
Jan 12, 2011·The British Journal of Dermatology·H L Tey, G Yosipovitch
Feb 8, 2011·Pain·Michael Von KorffConstance Weisner
Mar 10, 2011·Journal of Pain Research·Liliana L JorgeVitor Ep Teles
Mar 12, 2011·Journal of the American Geriatrics Society·Matthew MillerDaniel H Solomon
Apr 27, 2011·International Journal of Rheumatic Diseases·Anita Y N Lim, Michael Doherty
Jul 21, 2011·Drugs·Roy D Altman, H Richard Barthel
Aug 4, 2011·Journal of Pain Research·Sanford H Roth, Philip Fuller

❮ Previous
Next ❯

Citations

Sep 21, 2013·European Journal of Medicinal Chemistry·Lucie MaingotRebecca Deprez-Poulain
Jul 23, 2014·Current Medical Research and Opinion·Allan GibofskyClarence L Young
Mar 16, 2013·Current Medical Research and Opinion·Bill McCarberg, Penny Tenzer
Sep 25, 2014·American Journal of Therapeutics·Bill H McCarberg, Byron Cryer
Jul 22, 2015·Pain Management·Philip M Finch, Peter D Drummond
Aug 20, 2015·AAPS PharmSciTech·Shishu GoindiAtin Kalra
Jul 9, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society· AjazuddinDulal Krishna Tripathi
Oct 29, 2013·Clinical Therapeutics·Timothy J AtkinsonMaira Mirza
Apr 6, 2017·Clinical and Experimental Nephrology·Noboru OtsukaYoshio Terada
Jan 1, 2013·Health Services Insights·Mahsa TehraniJames D Katz
Dec 19, 2017·Pain Management·Bonifacio S RafananTuan Khanh Luong
Aug 23, 2018·The Nurse Practitioner·Scott J Saccomano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.