Evolution of toxicity in solitary nontoxic autonomously functioning thyroid nodules

The Journal of Clinical Endocrinology and Metabolism
J I Hamburger

Abstract

Between 1961 and 1979, 349 patients with autonomously functioning thyroid nodules (AFTN) were seen. There were 287 nontoxic and 62 toxic lesions. Toxic lesions were seen in 56.5% of AFTN patients over 60 yr of age but in only 12.5% of the younger patients. The female to male ratio was 14.9:1 for nontoxic AFTN patients but only 5.9:1 for toxic AFTN patients. The proportion of toxic AFTN in patients less than 20 yr old (13.8%) was not significantly different from that in patients 20--60 yr old (12.7%). T3 toxicosis was observed in 46% of those patients with hyperthyroidism. All but 4 of the toxic AFTN measured 3 cm in diameter or larger. AFTN 3 cm or larger were more than twice as common in patients 40 yr or older than in younger patients. Of 159 untreated nontoxic AFTN patients, 14 became toxic within 1--6 yr. One patient in 5 with a nontoxic AFTN 3 cm or larger developed toxicity.

Citations

Mar 1, 1991·Seminars in Surgical Oncology·T R Dorsch
Oct 1, 1986·World Journal of Surgery·C G ThomasS N Nayfeh
May 1, 1996·Annals of Nuclear Medicine·K NakadaN Tamaki
Jan 5, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Luis-Mauricio Hurtado-LópezCarlos Martínez-Duncker
Jul 11, 2001·Endocrinology and Metabolism Clinics of North America·D A Meier, M M Kaplan
Apr 16, 1998·Endocrinology and Metabolism Clinics of North America·D Zimmerman, A N Lteif
Apr 16, 1998·Endocrinology and Metabolism Clinics of North America·R D Siegel, S L Lee
Sep 5, 2001·Clinical Endocrinology·B CorvilainG Vassart
Dec 15, 1983·The New England Journal of Medicine·J Hamburger
May 24, 1984·The New England Journal of Medicine
Feb 25, 1993·The New England Journal of Medicine·E L Mazzaferri
Dec 4, 1997·The New England Journal of Medicine·R Paschke, M Ludgate
May 15, 1998·The New England Journal of Medicine·A R Hermus, D A Huysmans
Oct 22, 2004·The New England Journal of Medicine·Laszlo Hegedüs
Jun 30, 2007·Cancer Biotherapy & Radiopharmaceuticals·Otakar Kraft, Artur Stepien
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·B NygaardJ M Hansen
Feb 12, 1998·Thyroid : Official Journal of the American Thyroid Association·S TuminoA Belfiore
Apr 22, 1999·Thyroid : Official Journal of the American Thyroid Association·D A Koutras
Apr 25, 2000·Thyroid : Official Journal of the American Thyroid Association·P W SchneiderH Balon
Jan 8, 2008·Thyroid : Official Journal of the American Thyroid Association·Jennifer WakelingHarriet Syme
Jul 1, 1995·Clinical Endocrinology·J E DumontJ B Stanbury
Oct 12, 2011·Journal of Veterinary Internal Medicine·Jennifer WakelingHarriet Syme
Jan 1, 1990·Postgraduate Medical Journal·R Arem
Mar 1, 1990·Postgraduate Medical Journal·J W ElteA Haak
Nov 28, 1997·Postgraduate Medical Journal·A K SardaS Prasad
Jul 11, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Charles M IntenzoDavid M Capuzzi
May 7, 2013·Thyroid Research·Sasan MirfakhraeeJeffrey M Zigman
Jan 1, 1985·International Journal of Adolescent Medicine and Health·Arline L A Martin, Malcolm M Martin
Feb 22, 2008·AJR. American Journal of Roentgenology·Luciano TarantinoUmberto Parmeggiani
May 29, 2007·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Takashi HasegawaHideki Ito
Apr 1, 1987·Journal of Endocrinological Investigation·J D Wiener
Mar 27, 2012·The Medical Clinics of North America·Stuart C Seigel, Steven P Hodak
Nov 18, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Juanita K HodaxJose Bernardo Quintos
Jul 29, 2008·Neuroimaging Clinics of North America·Laurie A LoevnerGul Moonis
Nov 4, 2010·Clinical Endocrinology·Belinda J SchoutenJohn G Turner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
A BelfioreR Vigneri
The Journal of Clinical Endocrinology and Metabolism
Rodrigo Moreno-ReyesB Corvilain
The European Journal of General Practice
Jelle Stoffers
Thyroid : Official Journal of the American Thyroid Association
Eugenio ReschiniPaolo Gerundini
© 2021 Meta ULC. All rights reserved