Evolution of Traumatic Parenchymal Intracranial Hematomas (ICHs): Comparison of Hematoma and Edema Components

Frontiers in Neurology
Sean WilkesRamon Diaz-Arrastia

Abstract

This study seeks to quantitatively assess evolution of traumatic ICHs over the first 24 h and investigate its relationship with functional outcome. Early expansion of traumatic intracranial hematoma (ICH) is common, but previous studies have focused on the high density (blood) component. Hemostatic therapies may increase the risk of peri-hematoma infarction and associated increased cytotoxic edema. Assessing the magnitude and evolution of ICH and edema represented by high and low density components on computerized tomography (CT) may be informative for designing therapies targeted at traumatic ICH. CT scans from participants in the COBRIT (Citicoline Brain Injury Trial) study were analyzed using MIPAV software. CT scans from patients with non-surgical intraparenchymal ICHs at presentation and approximately 24 h later (±12 h) were selected. Regions of high density and low density were quantitatively measured. The relationship between volumes of high and low density were compared to several outcome measures, including Glasgow Outcome Score-Extended (GOSE) and Disability Rating Score (DRS). Paired scans from 84 patients were analyzed. The median time between the first and second scan was 22.79 h (25%ile 20.11 h; 75%ile 27.49 h). O...Continue Reading

References

Feb 1, 1994·Journal of Neurosurgery·A MarmarouK Demetriadou
Feb 1, 1994·Journal of Neurosurgery·M A Foda, A Marmarou
Jan 1, 1997·Acta Neurochirurgica. Supplement·A W UnterbergW Vollmann
Feb 3, 2004·Acta Neurochirurgica. Supplement·A Marmarou
Nov 25, 2004·Neuroscience·A W UnterbergK L Kiening
Nov 23, 2006·Neurology India·Yad R YadavAdam Nelson
Feb 27, 2007·Stroke; a Journal of Cerebral Circulation·Ryan WadaSean P Symons
Jul 7, 2007·Neurosurgical Focus·Danny LiangJ Marc Simard
Jul 7, 2007·Neurosurgical Focus·Tatsuro KawamataYoichi Katayama
May 16, 2008·The New England Journal of Medicine·Stephan A MayerUNKNOWN FAST Trial Investigators
May 22, 2008·Journal of Neurotrauma·Raj K NarayanUNKNOWN Traumatic Intracerebral Hemorrhage Study Group
Jan 23, 2009·The Journal of Head Trauma Rehabilitation·Heidi TerrioDeborah Warden
Nov 11, 2009·The Journal of Trauma·Christopher B AllardSandro B Rizoli
Oct 13, 2011·Journal of Neurotrauma·David KurlandJ Marc Simard
Nov 22, 2012·JAMA : the Journal of the American Medical Association·Ross D ZafonteSureyya S Dikmen
Oct 16, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Shahram MajidiAdnan I Qureshi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.