Evolution of tubulointerstitial fibrosis in experimental renal infection and scarring.

Journal of the American Society of Nephrology : JASN
Tim D HewitsonG J Becker

Abstract

Renal tubulointerstitial fibrosis may result from a loss of tubulointerstitial volume, which produces a disproportionate increase in the density of matrix. This study examines the relationship between fibrogenesis and collapse in scar formation after experimental renal infection. Escherichia coli were inoculated into the renal cortex of Sprague Dawley rats, with saline substituted in a control group. Glomerular, tubular, and interstitial profile areas were determined. Density of glomerular profiles was used as a measure of tubulointerstitial collapse. Collagen type I, III, and IV expression was examined by in situ hybridization and immunohistochemistry. Myofibroblasts were identified by alpha smooth muscle actin immunohistochemistry, and matrix metalloproteinase-1 (MMP-1) and MMP-2 were localized with appropriate antisera. Acute interstitial edema was followed by increasing density of glomerular profiles, paralleled by loss of interstitial volume and progressive tubular atrophy. Glomerular profile area remained unchanged. Density of glomerular profiles was not temporally related to myofibroblast accumulation. Procollagen alpha 1(I), alpha 1(III), and alpha 1(IV) transcription was focal, spatially related but temporally ordered....Continue Reading

Citations

Apr 11, 2000·Current Opinion in Nephrology and Hypertension·G J Becker, T D Hewitson
Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K J KelynackG J Becker
Oct 3, 1999·Journal of the American Society of Nephrology : JASN·T S JohnsonM Griffin
Apr 25, 2001·Kidney International·B Rodríguez-IturbeR J Johnson
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Darren J KellyMark E Cooper
Feb 22, 2002·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Sep 25, 2002·The Journal of Laboratory and Clinical Medicine·Tim D HewitsonGavin J Becker
May 20, 2004·Kidney International·Chrishan S SamuelRoger J Summers
Dec 31, 2004·Journal of the American Society of Nephrology : JASN·Markus LassilaMark E Cooper
Jun 9, 2005·Nephron. Experimental Nephrology·T D HewitsonG J Becker
May 13, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Timo JahnukainenGianni Celsi
Aug 6, 2005·Transplantation·Rosemary MastersonGavin Becker
Sep 16, 2006·The International Journal of Biochemistry & Cell Biology·Catherine E WinbanksGavin J Becker
Jan 25, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Manabu IchinoKiyotaka Hoshinaga
Nov 13, 2008·Phytotherapy Research : PTR·Lei JiYuan-yuan Gao
Dec 17, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ishanee MookerjeeChrishan S Samuel
Jan 16, 2009·American Journal of Physiology. Renal Physiology·Tim D Hewitson
May 7, 2009·Annals of the New York Academy of Sciences·Tim D Hewitson, Chrishan S Samuel
Sep 25, 2010·Journal of the American Society of Nephrology : JASN·Michael Zeisberg, Eric G Neilson
Feb 11, 2011·Kidney International·Jeffrey L Barnes, Yves Gorin
Sep 13, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael LianGavin J Becker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.