PMID: 9192645Jun 24, 1997Paper

Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus

Proceedings of the National Academy of Sciences of the United States of America
M A MartínezE Domingo

Abstract

Aphthoviruses use a conserved Arg-Gly-Asp triplet for attachment to host cells and this motif is believed to be essential for virus viability. Here we report that this triplet-which is also a widespread motif involved in cell-to-cell adhesion-can become dispensable upon short-term evolution of the virus harboring it. Foot-and-mouth disease virus (FMDV), which was multiply passaged in cell culture, showed an altered repertoire of antigenic variants resistant to a neutralizing monoclonal antibody. The altered repertoire includes variants with substitutions at the Arg-Gly-Asp motif. Mutants lacking this sequence replicated normally in cell culture and were indistinguishable from the parental virus. Studies with individual FMDV clones indicate that amino acid replacements on the capsid surface located around the loop harboring the Arg-Gly-Asp triplet may mediate in the dispensability of this motif. The results show that FMDV quasispecies evolving in a constant biological environment have the capability of rendering totally dispensable a receptor recognition motif previously invariant, and to ensure an alternative pathway for normal viral replication. Thus, variability of highly conserved motifs, even those that viruses have adapted...Continue Reading

References

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Citations

Oct 15, 2003·Journal of Molecular Biology·Carmen M Ruiz-JaraboEsteban Domingo
Mar 12, 2002·Virus Research·Esteban DomingoCristina Escarmis
Jan 16, 2003·Virus Research·Peter W MasonBarry Baxt
Jan 16, 2003·Virus Research·Terry JacksonElizabeth Fry
Sep 19, 1998·Clinical and Diagnostic Virology·E Domingo
Dec 17, 2009·Nature Structural & Molecular Biology·César SantiagoJosé M Casasnovas
Apr 16, 2004·Clinical Microbiology Reviews·Marvin J Grubman, Barry Baxt
Mar 23, 2000·Journal of Virology·C M Ruiz-JaraboE Domingo
Jul 23, 2002·Journal of Virology·Honey V Reddi, Howard L Lipton
Apr 15, 2003·Journal of Virology·Elizabeth E FryDavid I Stuart
Jun 13, 2012·Microbiology and Molecular Biology Reviews : MMBR·Esteban DomingoCelia Perales
Jun 11, 2003·BMC Microbiology·Claus O Wilke, Isabel S Novella
Apr 4, 2009·Current Opinion in Structural Biology·Thilo Stehle, José M Casasnovas
Aug 23, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Nicole Lewis-RogersKeith A Crandall
Jan 15, 2005·Virus Research·Nonia ParienteAntero Airaksinen
Dec 8, 2004·Journal of Molecular Biology·Celia PeralesEsteban Domingo
Apr 2, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Vítor BorgesJoão P Gomes
Dec 23, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Joern Klein
Aug 8, 2006·Journal of Molecular Biology·Verónica MartínEsteban Domingo

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