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Evolutionarily ancient BAH-PHD protein mediates Polycomb silencing

bioRxiv

Dec 6, 2019

Elizabeth T WilesEric U Selker

Abstract

Methylation of histone H3 lysine 27 (H3K27) is widely recognized as a transcriptionally repressive chromatin modification but the mechanism of repression remains unclear. We devised and implemented a forward genetic scheme to identify factors required for H3K27 methylation-mediated sile...read more

Mentioned in this Paper

Neurospora crassa
In Vivo
Homeo Domain
Genes
Pain Repression Pathway
Methylation
ASPH
PRC1 Protein
Asph protein, mouse
Gene Silencing by RNA
7
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Evolutionarily ancient BAH-PHD protein mediates Polycomb silencing

bioRxiv

Dec 6, 2019

Elizabeth T WilesEric U Selker

DOI: 10.1101/868117

Abstract

Methylation of histone H3 lysine 27 (H3K27) is widely recognized as a transcriptionally repressive chromatin modification but the mechanism of repression remains unclear. We devised and implemented a forward genetic scheme to identify factors required for H3K27 methylation-mediated sile...read more

Mentioned in this Paper

Neurospora crassa
In Vivo
Homeo Domain
Genes
Pain Repression Pathway
Methylation
ASPH
PRC1 Protein
Asph protein, mouse
Gene Silencing by RNA
7

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