Evolutionarily conserved glucocorticoid regulation of corticotropin-releasing factor expression

Endocrinology
Meng YaoRobert J Denver

Abstract

Glucocorticoids (GCs) exert feedback regulation on corticotropin-releasing factor (CRF) neurons in mammals. The nature of GC actions is cell-type specific, being either inhibitory (e.g. paraventricular nucleus) or stimulatory (e.g. amygdala and bed nucleus of the stria terminalis). Nothing is known about differential regulation of CRF gene expression by GCs in nonmammalian vertebrates. We studied the actions of GCs on CRF expression in discrete brain regions of the frog Xenopus laevis. Treatment with corticosterone (CORT) decreased, whereas the corticosteroid synthesis inhibitor metyrapone increased CRF expression in the anterior preoptic area (homolog of the mammalian paraventricular nucleus), as measured by CRF primary transcript, mRNA, and CRF immunoreactivity (ir) (by immunocytochemistry). By contrast to the preoptic area, CORT increased CRF-ir in the medial amygdala and bed nucleus of the stria terminalis, whereas metyrapone decreased CRF-ir in the medial amygdala. CRF-ir and glucocorticoid receptor-ir were colocalized in cells in the frog brain. In transient transfection assays in PC-12 cells, GCs decreased forskolin-induced activation of the frog CRF promoters. Treatment with CORT also reduced CRF promoter activity in tr...Continue Reading

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Citations

Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Christina S BarrMarkus Heilig
Apr 29, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chunjin Li, Xu Zhou
Apr 28, 2009·General and Comparative Endocrinology·Robert J Denver
Apr 11, 2008·The Journal of Comparative Neurology·Meng YaoRobert J Denver
May 22, 2009·Annals of the New York Academy of Sciences·Robert John Denver
May 22, 2009·Annals of the New York Academy of Sciences·Claudia LorenzWerner Kloas
Oct 8, 2014·Molecular Psychiatry·L TranB Greenwood-Van Meerveld
Oct 23, 2012·Psychoneuroendocrinology·L TranB Greenwood Van-Meerveld
Jan 11, 2016·Journal of Neuroendocrinology·B Greenwood-Van MeerveldM Vicario
Jun 1, 2017·International Journal of Molecular Sciences·Mónica Beatriz FrungieriSoledad Paola Rossi
Jan 18, 2012·Molecular Psychiatry·S R BornsteinR Levi-Montalcini
May 18, 2018·Cold Spring Harbor Protocols·Cristina Sáenz de MieraRobert J Denver
Apr 14, 2015·Molecular Endocrinology·Pia D BagamasbadRobert J Denver
Apr 4, 2020·Journal of Biological Rhythms·Joseph R KnoedlerRobert J Denver
Sep 26, 2013·Molecular Endocrinology·Andrew N EvansGreti Aguilera
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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