Evolutionary analyses of Sindbis virus strains isolated from mosquitoes in Kenya

Archives of Virology
Faith SigeiRosemary Sang

Abstract

Sindbis virus (SINV) is a mosquito borne virus maintained in nature in a mosquito-bird cycle, with human outbreaks known to occur in Northern Europe and parts of Africa. We analyzed five SINV strains isolated in Kenya from five different mosquito species and geographic locations between 2007 and 2013. Phylogenetic relationships and evolutionary inferences were performed using maximum likelihood and Bayesian phylogenetic inference approaches. Selection analyses were carried out based on the virus envelope glycoproteins (E1, E2) and non-structural protein (nsP4) genes. Phylogenetic analysis revealed that all the Kenyan SINV isolates belonged to genotype 1 with selection analyses suggesting that SINV E1, E2 and nsP4 protein encoding genes were predominantly evolving under negative selection.

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Citations

May 31, 2019·Journal of Virology·Jiaxin LingJenny C Hesson
Mar 11, 2020·Vector Borne and Zoonotic Diseases·Ali A MusaMaamun M Jeneby
Dec 10, 2020·Infection and Drug Resistance·Mingyuan HuangJincheng Zeng
Nov 9, 2020·The Lancet Infectious Diseases·Ali ZaidSuresh Mahalingam

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Datasets Mentioned

BETA
KY616984-KY616988

Methods Mentioned

BETA
PCR

Software Mentioned

Hyphy
Tracer
FigTree
MEME
DNA baser
TreeAnnotator
FUBAR
jModelTest
Muscle
BEAST

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