Apr 9, 2020

Topographic Connectivity in a Duration Selective Cortico-Cerebellar Network

BioRxiv : the Preprint Server for Biology
F. ProtopapaDomenica Bueti


How does the human brain represent millisecond unit of time? A recent neuroimaging study revealed the existence in the human premotor cortex of a topographic representation of time i.e., neuronal units selectively responsive to specific durations and topographically organized on the cortical surface. By using high resolution functional Magnetic Resonance Images here, we go futher this previous work, showing duration preferences across a wide network of cortical and subcortical brain areas: from cerebellum to primary visual, parietal, premotor and prefrontal cortices. Most importantly, we identify the functional connectivity structure between these different brain areas and their duration selective neural units. The results highlight the role of the cerebellum as the network hub and that of medial premotor cortex as the final stage of duration recognition. Interestingly, when a specific duration is presented, only the communication between the units selective to that duration become particularly active. These findings identify duration tuning and topographic connectivity as possible mechanisms underlying our capacity of telling time.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

RNA, Untranslated
Regulation of Biological Process
Sequence Determinations, RNA
SOX2-OT gene
Long Intergenic Non-Protein Coding RNA
RNA, Long Untranslated
Toxic Epidermal Necrolysis

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.