Evolutionary analysis of Tembusu virus: evidence for the emergence of a dominant genotype

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Li DaiPan Tao

Abstract

We recently identified Tembusu virus (TMUV) as a causative agent of duck infectious disease, which has spread in China since 2010. A recent study has indicated a potential case of human infection by TMUV, highlighting the need for further study of TMUV, especially its evolution. Because no information exists regarding the evolution of TMUV, we conducted comprehensive phylogenetic analyses using the largest collection of complete open reading frame (ORF) sequences of TMUV. Our results indicated that two lineages of viruses were associated with the 2010 outbreak in China, and lineage II, in particular sublineage II-c, has arisen as the dominant lineage currently circulating. We inferred that the most recent common ancestor (MRCA) of this TMUV was emerged around 1996. Evidence of natural recombination was also detected in TMUV. Molecular adaptation analyses revealed that strong negative selection shaped the evolution of TMUV, while a number of codons subjected to positive pressure were also identified. Our study, for the first time, illustrated the evolutionary history and character of TMUV and will be helpful for vaccine and diagnostic development.

References

Feb 1, 1992·Journal of Molecular Evolution·J M Smith
Feb 1, 1989·Nihon juigaku zasshi. The Japanese journal of veterinary science·S MiyazatoY Kono
Dec 22, 1999·Virology·M PadidamC M Fauquet
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·D Posada, K A Crandall
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
Feb 11, 2005·Molecular Biology and Evolution·Sergei L Kosakovsky Pond, Simon D W Frost
Feb 17, 2005·Bioinformatics·Sergei L Kosakovsky Pond, Simon D W Frost
Jun 23, 2006·PLoS Computational Biology·Sergei L Kosakovsky PondAndrew J Leigh Brown
Mar 21, 2008·Journal of Virology·Maciej F BoniEdward C Holmes
May 31, 2008·Molecular Biology and Evolution·Sergei L Kosakovsky PondSimon D W Frost
Jun 20, 2008·Bioinformatics·Art F Y PoonSergei L Kosakovsky Pond
Aug 28, 2010·Bioinformatics·Darren P MartinPierre Lefeuvre
Oct 18, 2011·Emerging Infectious Diseases·Zhenzhen CaoDabing Zhang
Jul 19, 2012·PLoS Genetics·Ben MurrellSergei L Kosakovsky Pond
Aug 1, 2012·Nature Methods·Diego DarribaDavid Posada
Dec 29, 2012·Research in Veterinary Science·Xinmei HuangYin Li
Apr 5, 2013·Transboundary and Emerging Diseases·Y TangC Yu
Aug 15, 2013·Virology Journal·Shuang LiJingliang Su
Sep 7, 2013·PLoS Neglected Tropical Diseases·Amy J SchuhAlan D T Barrett
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Apr 12, 2014·PLoS Computational Biology·Remco BouckaertAlexei J Drummond

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Citations

Mar 1, 2016·Frontiers in Microbiology·Jinfeng TiYouxiang Diao
Mar 10, 2018·Transboundary and Emerging Diseases·P NinvilaiA Thontiravong
May 16, 2019·Transboundary and Emerging Diseases·Patchareeporn NinvilaiAunyaratana Thontiravong
Nov 5, 2020·Avian Pathology : Journal of the W.V.P.A·Wikanda TunterakAunyaratana Thontiravong
Nov 19, 2020·Avian Diseases·Patchareeporn NinvilaiAunyaratana Thontiravong
Mar 30, 2021·Virus Research·Guiru QiuYong Wang
May 17, 2021·Transboundary and Emerging Diseases·Yingqi ZhuGuijun Wang

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