Apr 7, 2020

Analysis of stress responses in Astyanax larvae reveals heterogeneity among different populations

BioRxiv : the Preprint Server for Biology
J. S. R. ChinErik R Duboue

Abstract

Stress responses are conserved physiological and behavioral outcomes as a result of facing potentially harmful stimuli, yet in pathological states, stress becomes debilitating. Stress responses vary considerably throughout the animal kingdom, but how these responses are shaped evolutionarily is unknown. The Mexican cavefish has emerged as a powerful system for examining genetic principles underlying behavioral evolution. Here, we demonstrate that cave Astyanax have reduced behavioral and physiological measures of stress when examined at larval stages. We also find increased expression of the glucocorticoid receptor, a repressible element of the neuroendocrine stress pathway. Additionally, we examine stress in three different cave populations, and find that some, but not all, show reduced stress measures. Together, these results reveal a mechanistic system by which cave-dwelling fish reduced stress, presumably to compensate for a predator poor environment.

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Mentioned in this Paper

Metabolic Process, Cellular
Patterns
Pathological Fracture
Genome
Genes
Dependence
Gene Delivery Systems
Gene Transfer, Horizontal
Genomics
Chemical Substitution

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