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Evolutionary capacitance as a general feature of complex gene networks

Nature

Aug 2, 2003

Aviv Bergman, Mark L Siegal

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Abstract

An evolutionary capacitor buffers genotypic variation under normal conditions, thereby promoting the accumulation of hidden polymorphism. But it occasionally fails, thereby revealing this variation phenotypically. The principal example of an evolutionary capacitor is Hsp90, a molecular ...read more

Mentioned in this Paper

Saccharomyces cerevisiae Proteins
Buffers
Exertion
Arabidopsis
Gene Deletion Abnormality
HSP90AA1 gene
Gene Deletion
Drosophila
Gene Expression Regulation, Fungal
HSP90 Heat-Shock Proteins
1
452
1
Paper Details
References
  • References23
  • Citations244
123
  • References23
  • Citations244
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Evolutionary capacitance as a general feature of complex gene networks

Nature

Aug 2, 2003

Aviv Bergman, Mark L Siegal

PMID: 12891357

DOI: 10.1038/nature01765

Abstract

An evolutionary capacitor buffers genotypic variation under normal conditions, thereby promoting the accumulation of hidden polymorphism. But it occasionally fails, thereby revealing this variation phenotypically. The principal example of an evolutionary capacitor is Hsp90, a molecular ...read more

Mentioned in this Paper

Saccharomyces cerevisiae Proteins
Buffers
Exertion
Arabidopsis
Gene Deletion Abnormality
HSP90AA1 gene
Gene Deletion
Drosophila
Gene Expression Regulation, Fungal
HSP90 Heat-Shock Proteins
1
452
1

Feeds With Similar Papers

Chaperones & Protein Folding

Chaperones are proteins that play an essential role in protein folding, stability, assembly, and degradation. Their depletion or dysfunction has been implicated in protein folding disorders. Here is the latest research.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Waddington's canalization revisited: developmental stability and evolution

Proceedings of the National Academy of Sciences of the United States of AmericaJune 26, 2002
Mark L Siegal, Aviv Bergman
Paper Details
References
  • References23
  • Citations244
123
  • References23
  • Citations244
12345...

Download from

Publisher
PubMed
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