Evolutionary conservation of complexins: from choanoflagellates to mice

EMBO Reports
Xiaofei YangT C Südhof

Abstract

Complexins are synaptic SNARE complex-binding proteins that cooperate with synaptotagmins in activating Ca(2+)-stimulated, synaptotagmin-dependent synaptic vesicle exocytosis and in clamping spontaneous, synaptotagmin-independent synaptic vesicle exocytosis. Here, we show that complexin sequences are conserved in some non-metazoan unicellular organisms and in all metazoans, suggesting that complexins are a universal feature of metazoans that predate metazoan evolution. We show that complexin from Nematostella vectensis, a cnidarian sea anemone far separated from mammals in metazoan evolution, functionally replaces mouse complexins in activating Ca(2+)-triggered exocytosis, but is unable to clamp spontaneous exocytosis. Thus, the activating function of complexins is likely conserved throughout metazoan evolution.

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Citations

Jul 23, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ying LaiAxel T Brunger
Nov 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jihong GongJiajie Diao
Sep 2, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Pawel Burkhardt, Simon G Sprecher
May 25, 2018·Annual Review of Biophysics·Axel T BrungerQiangjun Zhou
Jul 4, 2019·Integrative and Comparative Biology·Sally P LeysAmanda S Kahn
Jul 19, 2017·The Journal of Eukaryotic Microbiology·Helmut Plattner
Mar 23, 2017·Frontiers in Cellular Neuroscience·Masaaki Sato
Feb 9, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ronja GöhdePawel Burkhardt
May 1, 2018·Trends in Cell Biology·Axel T BrungerYing Lai

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