PMID: 6165796Feb 1, 1981Paper

Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man

The Journal of Experimental Medicine
J A LedbetterL A Herzenberg

Abstract

We describe the biochemical properties and cell surface distributions of three human T cell antigens (Leu-1, Leu-2a, and Leu-2b) which we postulate to be the homologues of the Lyt-1, Lyt-2, and Lyt-3 antigens that distinguish functional T cell subsets in the mouse. Leu-l, like Lyt-1, is on all thymocytes and peripheral T cells and is present in greater amounts on the helper/inducer subset than on the cytotoxic/suppressor subset. Both antigens increase in parallel fashion during T cell maturation in the thymus and each antigen is carried on a single 67,000-molecular weight (relative) (M(r)) polypeptide chain. Surprisingly, Leu-1 and Lyt-1 each are also expressed in readily detectable amounts on some B celI Ieukemias but not detectably so on normal B cells. Leu-2a and Leu-2b are antigens found only on suppressor/cytotoxic cells in the human and are very similar to the murine Lyt-2 and Lyt-3 antigens. In both species, the two antigens are on the same disulfide- linked multimeric molecules. Disulfide-bond reduction in both species yields subunits of similar size and charge. Lyt-3 and Leu-2b are extremely sensitive to trypsin digestion on viable cells whereas Lyt-2 and Leu-2a are much less so. A different membrane antigen, Leu-3, is...Continue Reading

References

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Citations

Jan 1, 1988·Rheumatology International·P YouinouP Angelidis
Jan 1, 1985·Human Genetics·G BrunsL A Herzenberg
Jul 1, 1988·Transplant International : Official Journal of the European Society for Organ Transplantation·D MaraninchiG Novakovitch
Jan 1, 1983·Immunogenetics·N FlomenbergB Dupont
Jan 1, 1984·Immunogenetics·J S TungE A Boyse
Jan 1, 1985·Archives of Dermatological Research·A R Ahmed
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·M DrijkoningenV Desmet
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·J BerlingS von Kleist
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y TsutsumiK Watanabe
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·H O WintzerB Forster
Sep 1, 1984·Biulleten' eksperimental'noĭ biologii i meditsiny·A Iu Baryshnikov
Apr 1, 1987·Biulleten' eksperimental'noĭ biologii i meditsiny·A V ChervonskiĭB D Brondz
Nov 1, 1987·Journal of Clinical Immunology·O TaniguchiK Okumura
Nov 1, 1987·Journal of Clinical Immunology·R GerliP Rambotti
Jul 1, 1983·Journal of Clinical Immunology·A R AhmedA S Saxon
Oct 1, 1983·Journal of Clinical Immunology·E BenvenisteM S Gottlieb
Jul 1, 1987·Digestive Diseases and Sciences·K D LindorS J Beaver
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·M ShiotaS Mori
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·T NakanomaJ Hata
Jan 1, 1982·Springer Seminars in Immunopathology·J W Goding
Jan 1, 1982·Springer Seminars in Immunopathology·M C MingariL Moretta
Jan 1, 1984·Springer Seminars in Immunopathology·C B Carpenter, T B Strom
Jan 1, 1985·Acta diabetologica latina·E R RichensR W Groves
Dec 21, 2005·Rheumatology International·Matthias F SeidelHans Vetter
Jan 1, 1981·Journal of Immunological Methods·S FongJ H Vaughan

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