Evolutionary conservation of the sulfated oligosaccharides on vertebrate glycoprotein hormones that control circulatory half-life.

The Journal of Biological Chemistry
S M ManzellaJ U Baenziger

Abstract

The circulatory half-life of the mammalian glycoprotein hormone lutropin is controlled by its unique Asn-linked oligosaccharides, which terminate with the sequence SO4-4-GalNAc beta 1,4GlcNAc. A cluster of basic amino acids essential for recognition of the alpha subunit by the glycoprotein hormone:N-acetylgalactosaminyltransferase is located within two turns of an alpha helix (Mengeling, B.J., Manzella, S.M., and Baenziger, J.U. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 502-506). The amino acids within this region are virtually invariant in the alpha subunits of all vertebrates, indicating that the recognition determinant utilized by the N-acetylgalactosaminyltransferase has been conserved in species ranging from teleost fish to mammals. We demonstrate that the glycoprotein hormone:N-acetylgalactosaminyltransferase and the N-acetylgalactosamine-4-sulfotransferase responsible for the synthesis of these unique sulfated oligosaccharides are expressed in the pituitaries of vertebrates ranging from teleost fish to mammals. Furthermore, we show that Asn-linked oligosaccharides terminating with SO4-4-GalNAc beta 1,4GlcNAc are present on the alpha and beta subunits of the salmon glycoprotein hormone GTH II. Asn-linked oligosaccharides t...Continue Reading

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Citations

May 5, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Finn-Arne WeltzienBirgitta Norberg
Apr 8, 2003·General and Comparative Endocrinology·Finn-Arne WeltzienPenny Swanson
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·D J FieteJ U Baenziger
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·D S Roseman, J U Baenziger
Jul 1, 1996·Journal of Protein Chemistry·V Y ButnevG R Bousfield
Oct 10, 2002·Endocrine Reviews·Charles A Strott
Jul 10, 2019·Glycobiology·Noriko Suzuki
May 24, 1996·The Journal of Biological Chemistry·S M ManzellaJ U Baenziger
Jun 6, 1997·The Journal of Biological Chemistry·D Fiete, J U Baenziger
Mar 11, 2016·The Journal of Biological Chemistry·Kurutihalli S VishwanathaBetty A Eipper
Aug 2, 2020·Molecular & Cellular Proteomics : MCP·Haiying LiRichard S Lee
Aug 10, 2000·Analytical Biochemistry·K G Rice
Jan 8, 2003·The Journal of Organic Chemistry·Joshua I ArmstrongCarolyn R Bertozzi

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