Evolutionary determinants of genome-wide nucleotide composition

Nature Ecology & Evolution
Hongan LongMichael Lynch

Abstract

One of the long-standing mysteries of evolutionary genomics is the source of the wide phylogenetic diversity in genome nucleotide composition (G + C versus A + T), which must be a consequence of interspecific differences in mutation bias, the efficiency of selection for different nucleotides or a combination of the two. We demonstrate that although genomic G + C composition is strongly driven by mutation bias, it is also substantially modified by direct selection and/or as a by-product of biased gene conversion. Moreover, G + C composition at fourfold redundant sites is consistently elevated above the neutral expectation-more so than for any other class of sites.

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Citations

May 26, 2018·G3 : Genes - Genomes - Genetics·Hongan LongMichael Lynch
Jun 21, 2019·Genome Biology and Evolution·Marc KrasovecGwenael Piganeau
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Datasets Mentioned

BETA
PRJNA376572

Methods Mentioned

BETA
Illumina sequencing

Software Mentioned

Integrated Genome Viewer
HaplotypeCaller
GATK

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