Apr 17, 2020

First-generation EGFR-TKI plus chemotherapy versus EGFR-TKI alone as first-line treatment in advanced NSCLC with EGFR activating mutation: a systematic review and meta-analysis of randomized controlled trials

BioRxiv : the Preprint Server for Biology
Q. WuFeng Xu


The role of addition of chemotherapy (CT) to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for EGFR-mutated non-small cell lung cancer (NSCLC) has not been well established. The aim of this meta-analysis was to evaluate efficacy and toxicity of EGFR-TKI in combination with CT compared to EGFR-TKI monotherapy as first-line treatment in advanced NSCLC harboring EGFR activating mutation. A systematic literature search of randomized controlled trials using Cochrane Library, PubMed, Embase, and Web of Science, was performed up to Jan. 7th, 2020. A total of eight randomized trials involving 1,349 advanced NSCLC patients with sensitive EGFR mutation were included in the meta-analysis. All patients in both groups received first-generation TKI as first-line treatment. The pooled hazard ratios (HRs) of progression-free survival (PFS) and overall survival (OS) were 0.56 (95% CI=0.50-0.64; P < 0.00001) and 0.70 (95% CI=0.54-0.90; P=0.005), respectively. Subgroup analysis showed significantly higher OS advantages in patients receiving doublet CT (P=0.02) and concurrent therapy (P=0.002). The objective response rate (ORR) in the EGFR-TKI plus CT group was significantly higher than in the EGFR-TKI monotherapy group (RR...Continue Reading

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Gene Polymorphism
Positioning Attribute
Portuguese Population
Isthmus of the Cingulate Gyrus

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Biological Reviews of the Cambridge Philosophical Society
Carolann R SchackKen G Ryan
Edinburgh Medical and Surgical Journal
John A Lidell
D F Sawbridge, M A Bell
© 2020 Meta ULC. All rights reserved