Evolutionary divergence of Ure2pA glutathione transferases in wood degrading fungi

Fungal Genetics and Biology : FG & B
Thomas RoretMélanie Morel-Rouhier

Abstract

The intracellular systems of detoxification are crucial for the survival of wood degrading fungi. Within these systems, glutathione transferases could play a major role since this family of enzymes is specifically extended in lignolytic fungi. In particular the Ure2p class represents one third of the total GST number in Phanerochaete chrysosporium. These proteins have been phylogenetically split into two subclasses called Ure2pA and Ure2pB. Ure2pB can be classified as Nu GSTs because of shared structural and functional features with previously characterized bacterial isoforms. Ure2pA can rather be qualified as Nu-like GSTs since they exhibit a number of differences. Ure2pA possess a classical transferase activity, a more divergent catalytic site and a higher structural flexibility for some of them, compared to Nu GSTs. The characterization of four members of this Ure2pA subclass (PcUre2pA4, PcUre2pA5, PcUre2pA6 and PcUre2pA8) revealed specific functional and structural features, suggesting that these enzymes have rapidly evolved and differentiated, probably to adapt to the complex chemical environment associated with wood decomposition.

References

Nov 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Boris Magasanik
Dec 22, 2005·Acta Crystallographica. Section D, Biological Crystallography·Philip Evans
Oct 11, 2008·Journal of Molecular Biology·Zai-Rong ZhangSarah Perrett
Mar 27, 2009·The Journal of Biological Chemistry·Zai-Rong Zhang, Sarah Perrett
Jan 9, 2010·Acta Crystallographica. Section D, Biological Crystallography·Alexei Vagin, Alexei Teplyakov
Feb 4, 2010·Acta Crystallographica. Section D, Biological Crystallography·Wolfgang Kabsch
Feb 4, 2010·Acta Crystallographica. Section D, Biological Crystallography·Paul D AdamsPeter H Zwart
Apr 13, 2010·Acta Crystallographica. Section D, Biological Crystallography·P EmsleyK Cowtan
Nov 26, 2010·Biochemical and Biophysical Research Communications·Jérémy CouturierNicolas Rouhier
Oct 18, 2011·Biochemistry·John A GerltJonathan V Sweedler
Dec 14, 2011·International Journal of Evolutionary Biology·Anne ThuillierMélanie Morel
Jan 3, 2013·Microbial Biotechnology·Mélanie MorelEric Gelhaye
Feb 13, 2013·Journal of Molecular Evolution·Sun Shim Choi, Sridhar Hannenhalli
May 29, 2013·FEBS Letters·Anne ThuillierMélanie Morel-Rouhier
Dec 4, 2013·Nucleic Acids Research·Igor V GrigorievIgor Shabalov
Jun 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Robert RileyIgor V Grigoriev
Aug 12, 2014·Applied and Environmental Microbiology·Anne ThuillierMélanie Morel-Rouhier
Jan 8, 2015·Frontiers in Plant Science·Henri PégeotNicolas Rouhier

❮ Previous
Next ❯

Citations

Sep 14, 2018·Environmental Microbiology·Antonio José Fernández-GonzálezMélanie Morel-Rouhier
Jun 13, 2020·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Shingo MiyauchiMarie-Noëlle Rosso
Apr 29, 2021·Angewandte Chemie·Kirstin ScherlachEva M Huber
Oct 2, 2020·Journal of Natural Products·Muriel BarbierEric Gelhaye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biodiversity Data

Biodiversity refers to the variety and variability of life on Earth. Biodiversity is typically a measure of variation at the genetic, species, and ecosystem level.Discover the latest research on biodiversity data here.