Evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii circulating in Chilean hospitals

BioRxiv : the Preprint Server for Biology
Andres Opazo-CapurroGerardo Enrique González-Rocha

Abstract

We analyze the evolutionary dynamics of ninety carbapenem-resistant Acinetobacter baumannii (CRAB) isolates collected between 1990 and 2015 in Chile. CRAB were identified at first in an isolate collected in 2005, which harbored the IS Aba1 - bla OXA-69 arrangement. Later, OXA-58- and OXA-23-producing A. baumannii strains emerged in 2007 and 2009, respectively. This phenomenon was associated with variations in the epidemiology of OXA-type carbapenemases, linked to nosocomial lineages belonging to ST109 (CC1), ST162 (CC79), ST15 (CC15) and ST318 (CC15).

Related Concepts

Epidemiology
Hospitals
Carbapenemase
Acinetobacter baumannii
Oxytocin, Asp(5)-
St15 protein, Dictyostelium discoideum
Rb1cc1 protein, mouse
HAB1 protein, Arabidopsis

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