Evolutionary dynamics of HIV at multiple spatial and temporal scales.

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Alison L HillM A Nowak

Abstract

Infectious diseases remain a formidable challenge to human health, and understanding pathogen evolution is crucial to designing effective therapeutics and control strategies. Here, we review important evolutionary aspects of HIV infection, highlighting the concept of selection at multiple spatial and temporal scales. At the smallest scale, a single cell may be infected by multiple virions competing for intracellular resources. Recombination and phenotypic mixing introduce novel evolutionary dynamics. As the virus spreads between cells in an infected individual, it continually evolves to circumvent the immune system. We discuss evolutionary mechanisms of HIV pathogenesis and progression to AIDS. Viral spread throughout the human population can lead to changes in virulence and the transmission of immune-evading variation. HIV emerged as a human pathogen due to selection occurring between different species, adapting from related viruses of primates. HIV also evolves resistance to antiretroviral drugs within a single infected host, and we explore the possibility for the spread of these strains between hosts, leading to a drug-resistant epidemic. We investigate the role of latency, drug-protected compartments, and direct cell-to-cel...Continue Reading

References

Mar 1, 1976·The Quarterly Review of Biology·S C Stearns
Nov 15, 1991·Science·M A NowakR M May
Sep 1, 1991·Mathematical Biosciences·M A Nowak, R M May
Mar 12, 1987·Nature·R M May, R M Anderson
Oct 22, 1983·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R M May, R M Anderson
Aug 22, 1995·Proceedings. Biological Sciences·R M May, M A Nowak
Oct 15, 1994·Statistics in Medicine·D Schenzle
Jan 22, 1994·Proceedings. Biological Sciences·M A Nowak, R M May
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·A J Brown
May 22, 1997·Proceedings. Biological Sciences·S Bonhoeffer, M A Nowak
Jun 19, 1998·Journal of Theoretical Biology·R R RegoesM A Nowak
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·I M Rouzine, J M Coffin
May 4, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D WodarzM A Nowak
Mar 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A S Fauci
Jan 31, 2002·Annual Review of Medicine·Welkin E Johnson, Ronald C Desrosiers
Jan 31, 2002·Annual Review of Medicine·Joel N BlanksonRobert F Siliciano
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Beverly A Smith-FranklinGregory F Burton
Mar 2, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Haynes W SheppardSusan P Buchbinder
Mar 22, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shane CrottyRaul Andino
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Niko BeerenwinkelJoachim Selbig
Jul 12, 2002·Nature·Andreas JungAndreas Meyerhans
Sep 18, 2002·Journal of Theoretical Biology·Roland Regoes, Sebastian Bonhoeffer
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Manfred Eigen
Oct 25, 2002·Proceedings. Biological Sciences·Christel Kamp, Stefan Bornholdt
Mar 21, 2003·Nature·Xiping WeiGeorge M Shaw
May 17, 2003·Science·Denise LecossierAllan J Hance
Jun 11, 2003·BMC Microbiology·Claus O Wilke, Isabel S Novella
Jun 18, 2003·Cell·Reuben S HarrisMichael H Malim
Jun 18, 2003·The Journal of General Virology·Judie B AlimontiKeith R Fowke
Jul 12, 2003·Bioinformatics·Niko BeerenwinkelJoachim Selbig
Dec 9, 2003·The Journal of Clinical Investigation·Dennis G CvitkovitchRichard P Ellen
Jan 7, 2004·Nature Reviews. Genetics·Andrew RambautEdward C Holmes
Jan 22, 2004·The Journal of Experimental Medicine·Clare JollyQuentin J Sattentau

❮ Previous
Next ❯

Citations

May 1, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Detlev Ganten, Randolph Nesse
Sep 4, 2012·Nature Medicine·Daniel I S RosenbloomMartin A Nowak
Jul 31, 2013·Current Opinion in Virology·Christian Selinger, Michael G Katze
Mar 1, 2012·Frontiers in Life Science·Richard A LeaseChristophe Lavelle
Jan 31, 2018·Retrovirology·Gert van ZylMary F Kearney
Apr 5, 2014·American Journal of Speech-language Pathology·Sharynne McLeod, Sarah Verdon
May 20, 2017·American Journal of Speech-language Pathology·Sharynne McLeodUNKNOWN International Expert Panel on Multilingual Children's Speech

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

The Journal of General Virology
Cecilia T Costiniuk, Mohammad-Ali Jenabian
Journal of Acquired Immune Deficiency Syndromes : JAIDS
H M Temin
Acta Paediatrica. Supplement
R HoffM McCauley
Current Opinion in HIV and AIDS
Zenda Woodman, Carolyn Williamson
Clinical Microbiology Reviews
Véronique Avettand-FènoëlChristine Rouzioux
© 2021 Meta ULC. All rights reserved