Aug 11, 2000

Evolutionary dynamics of pathogen resistance and tolerance

Evolution; International Journal of Organic Evolution
B A Roy, J W Kirchner

Abstract

Host organisms can respond to the threat of disease either through resistance defenses (which inhibit or limit infection) or through tolerance strategies (which do not limit infection, but reduce or offset its fitness consequences). Here we show that resistance and tolerance can have fundamentally different evolutionary outcomes, even when they have equivalent short-term benefit for the host. As a gene conferring disease resistance spreads through a population, the incidence of infection declines, reducing the fitness advantage of carrying the resistance gene. Thus genes conferring complete resistance cannot become fixed (i.e., universal) by selection in a host population, and diseases cannot be eliminated solely by natural selection for host resistance. By contrast, as a gene conferring disease tolerance spreads through a population, disease incidence rises, increasing the evolutionary advantage of carrying the tolerance gene. Therefore, any tolerance gene that can invade a host population will tend to be driven to fixation by selection. As predicted, field studies of diverse plant species infected by rust fungi confirm that resistance traits tend to be polymorphic and tolerance traits tend to be fixed. These observations sugg...Continue Reading

  • References12
  • Citations190

References

Mentioned in this Paper

Filamentous fungus
Genetics, Population
Sample Fixation
Genes, vif
Disease Resistance
Parasitic Diseases
Uredinales
Plant Diseases
Metazoa
Biological Evolution

About this Paper

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