Evolutionary dynamics of redundant regulatory control.

Journal of Theoretical Biology
Steven A Frank

Abstract

Many complex regulatory processes concern tracking a constant or variable set point. Examples include temperature homeostasis, rhythmic oscillation, and the concentration of key metabolites and enzymes. Control over homeostatic or tracking phenotypes often depends on multiple, overlapping regulatory systems. In this paper, I develop a theory for the evolutionary dynamics of redundant regulatory control architecture. Prior theories analyzed the evolution of redundant control architectures by the balance between improved performance for additional redundant control weighed against the decay by germline mutation that arises in characters with overlapping function. By contrast, I argue that germline mutation is likely to be a very weak balancing force in evolutionary dynamics. Instead, I analyze the evolutionary dynamics of redundant control by a balance between the benefits of reduced tracking error and the costs of building and running the multiple control systems. In one particular mathematical model that highlights key features of evolutionary dynamics, additional redundant control reduces tracking error multiplicatively but contributes to costs additively. In that model, the performance landscape has multiple peaks of the same...Continue Reading

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Citations

Jul 16, 2010·PLoS Computational Biology·Tiago Paixão, Ricardo B R Azevedo
Nov 3, 2009·Bio Systems·Robert A Laird, Thomas N Sherratt
Jun 27, 2017·Trends in Ecology & Evolution·Matthew D HallDieter Ebert
Jun 3, 2009·Expert Review of Anti-infective Therapy·Hamza A BabikerGöte Swedberg

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