Evolutionary dynamics of the immunoglobulin heavy chain variable region genes in vertebrates

Immunogenetics
Sabyasachi DasMasatoshi Nei

Abstract

Immunoglobulin heavy chains are polypeptides encoded by four genes: variable (IGHV), joining (IGHJ), diversity (IGHD), and constant (IGHC) region genes. The number of IGHV genes varies from species to species. To understand the evolution of the IGHV multigene family, we identified and analyzed the IGHV sequences from 16 vertebrate species. The results show that the numbers of functional and nonfunctional IGHV genes among different species are positively correlated. The number of IGHV genes is relatively stable in teleosts, but the intragenomic sequence variation is generally higher in teleosts than in tetrapods. The IGHV genes in tetrapods can be classified into three phylogenetic clans (I, II, and III). The clan III and/or II genes are relatively abundant, whereas clan I genes exist in small numbers or are absent in most species. The genomic organization of clan I, II, and III IGHV genes varies considerably among species, but the entire IGHV locus seems to be conserved in the subtelomeric or near-centromeric region of chromosome. The presence or absence of specific IGHV clan members and the lineage-specific expansion and contraction of IGHV genes indicate that the IGHV locus continues to evolve in a species-specific manner. Ou...Continue Reading

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Citations

May 6, 2010·Immunogenetics·Jacobus HendricksFrans G M Kroese
Apr 10, 2013·Developmental and Comparative Immunology·Rebecca L TallmadgeM Julia B Felippe
Oct 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sabyasachi DasMasatoshi Nei
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sabyasachi DasMax D Cooper
May 12, 2010·Molecular Biology and Evolution·Sabyasachi DasMax D Cooper
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