Evolutionary engineering of industrial microorganisms-strategies and applications

Applied Microbiology and Biotechnology
Zhengming ZhuGuocheng Du

Abstract

Microbial cells have been widely used in the industry to obtain various biochemical products, and evolutionary engineering is a common method in biological research to improve their traits, such as high environmental tolerance and improvement of product yield. To obtain better integrate functions of microbial cells, evolutionary engineering combined with other biotechnologies have attracted more attention in recent years. Classical laboratory evolution has been proven effective to letting more beneficial mutations occur in different genes but also has some inherent limitations such as a long evolutionary period and uncontrolled mutation frequencies. However, recent studies showed that some new strategies may gradually overcome these limitations. In this review, we summarize the evolutionary strategies commonly used in industrial microorganisms and discuss the combination of evolutionary engineering with other biotechnologies such as systems biology and inverse metabolic engineering. Finally, we prospect the importance and application prospect of evolutionary engineering as a powerful tool especially in optimization of industrial microbial cell factories.

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Citations

May 10, 2019·Biotechnology Journal·Lorena Fernández-CabezónPablo I Nikel
Aug 16, 2019·Journal of Industrial Microbiology & Biotechnology·Zhengming ZhuGuocheng Du
Jul 19, 2020·World Journal of Microbiology & Biotechnology·Mengxue Peng, Zhihong Liang
Jul 1, 2019·Applied Microbiology and Biotechnology·Xueliang QiuGuocheng Du
Sep 21, 2018·Journal of Industrial Microbiology & Biotechnology·Zhengming ZhuGuocheng Du
Sep 25, 2020·World Journal of Microbiology & Biotechnology·Liang ChenKe Bian

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Methods Mentioned

BETA
PCR
fluorescence-activated cell sorting
FACS
environmental stress

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