Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis

Marine Genomics
Gouranga BiswasMasahiro Sakai

Abstract

Tumor necrosis factor (TNF) and its superfamily (TNFSF) members are important inflammatory cytokines. Although fish have fourteen TNFSF genes, their genomic location and existence are yet to be described and confirmed in the Japanese pufferfish (Fugu) (Takifugu rubripes). Therefore, we conducted in silico identification, synteny analysis of TNFSF genes from Fugu with that of zebrafish and human TNFSF loci and their expression analysis in various tissues. We identified ten novel TNFSF genes, viz. TNFSF5 (CD40L), TNFSF6 (FasL), three TNFSF10 (TRAIL) (-1, 2 and 3), TNFSF11 (RANKlg), TNFSF12 (TWEAK), two TNFSF13B (BAFF) (1 and 2) and TNFSF14 (LIGHT) belonging to seven TNFSFs in Fugu. Several features such as existence of TNF family signature, conservation of genes in TNF loci with human and zebrafish chromosomes and phylogenetic clustering with other teleost TNFSF orthologs confirmed their identity. Fugu TNFSF genes were constitutively expressed in all eight different tissues with most of them expressed highly in liver. Fugu TNFSF10 gene has three homologs present on chromosomes 10 (TNFSF10-1), 8 (TNFSF10-2) and 2 (TNFSF10-3). Moreover, a phylogenetic analysis containing all available vertebrate (mammals, birds, reptiles, amphibian...Continue Reading

References

Nov 1, 1996·Immunology Today·I N Crispe, W Z Mehal
Aug 10, 2000·Journal of Virology·P ClarkeK L Tyler
Mar 7, 2001·European Journal of Biochemistry·K J LaingC J Secombes
Feb 28, 2002·Trends in Immunology·Fabienne Mackay, Charles R Mackay
Jun 18, 2002·The EMBO Journal·Tatsushi IgakiMasayuki Miura
Jun 27, 2002·The Journal of Biological Chemistry·Hiroshi KandaMasayuki Miura
Jul 13, 2002·European Journal of Immunology·Antonius G RolinkFritz Melchers
Jul 27, 2002·Science·Samuel AparicioSydney Brenner
Dec 13, 2002·Developmental and Comparative Immunology·Jeroen P J SaeijGeert F Wiegertjes
Jun 24, 2003·Developmental and Comparative Immunology·J ZouC J Secombes
Jul 16, 2003·Trends in Immunology·Yves ColletteDaniel Olive
Sep 2, 2003·Nature Reviews. Immunology·Bharat B Aggarwal
Feb 13, 2004·Marine Biotechnology·M S ClarkG Elgar
Oct 22, 2004·Nature·UNKNOWN International Human Genome Sequencing Consortium
Dec 14, 2004·Nature·UNKNOWN International Chicken Genome Sequencing Consortium
Aug 19, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Axel Meyer, Yves Van de Peer
Aug 5, 2006·Cell Death and Differentiation·P M EimonA Ashkenazi
Nov 9, 2007·Developmental and Comparative Immunology·Leon GrayferMiodrag Belosevic
Mar 18, 2008·Molecular Phylogenetics and Evolution·Wei Zhang, Zhirong Sun
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Dec 20, 2008·Current Opinion in Genetics & Development·Vydianathan Ravi, Byrappa Venkatesh
Jul 25, 2009·Nature Reviews. Cancer·Erwin F Wagner, Angel R Nebreda
Mar 1, 2006·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Ram Savan, Masahiro Sakai
Apr 30, 2011·Developmental and Comparative Immunology·Gregory D Wiens, Gavin W Glenney
Jan 29, 2013·Developmental and Comparative Immunology·Narayan Prasad PanditJiale Li
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Jan 10, 2014·Nature·Byrappa VenkateshWesley C Warren

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Citations

May 18, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomoki MaedaToshiaki Miyadai
Jul 29, 2020·Science China. Life Sciences·Yaoguo LiJun Zou
May 15, 2021·Developmental and Comparative Immunology·Yulu DuanChun Xia

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