Evolutionary evidence suggests that CpG island-associated Alus are frequently unmethylated in human germline

Human Genetics
Jesper Brohede, Keith N Rand

Abstract

Most Alu elements are considered to belong to the methylated fraction of the genome that has undergone CpG depletion, whereas CpG islands are characteristically unmethylated. By analysing the CpG content of >12,000 autosomal CpG island-Alu Sx pairs we wanted to study what happens when an Alu is situated close to a CpG island. We have found that many Alus located close to CpG islands have retained a high proportion of CpG sites, which is consistent with these Alus being unmethylated in the human germline.

References

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Citations

May 22, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Tae-Min KimMyeong Ho Jung
Jan 8, 2011·Molecular Biology and Evolution·Lars FeuerbachJotun Hein
Dec 18, 2007·Nucleic Acids Research·Jairo RodriguezMiguel A Peinado
Jan 30, 2008·Gene·Fabrício F Costa
Mar 19, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nikolai V Tomilin
Feb 12, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Berta MartínMireia Jordà

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