Evolutionary expansion and structural functionalism of the ancient family of profilin proteins

Gene
Dhananjay K Pandey, Bhupendra Chaudhary

Abstract

Structure and functional similarities of a recent protein's orthologs with its ancient counterpart are largely determined by the configuration of evolutionary preservation of amino acids. The emergence of genome sequencing databases allowed dissecting the evolutionarily important gene families at a comprehensive and genome-wide scale. The profilin multi-gene family is an ancient, universal, and functionally diverged across kingdoms, which regulates various aspects of cellular development in both prokarya and eukarya, especially cell-wall maintenance through actin sequestering, nucleation and cytokinesis. We performed a meta-analysis of the evolutionary expansion, structural conservation, evolution of function motifs, and transcriptional biases of profilin proteins across kingdoms. An exhaustive search of various genome databases of cyanobacteria, fungi, animalia and plantae kingdoms revealed 172 paralogous/orthologous profilins those were phylogenetically clustered in various groups. Orthologous gene comparisons indicated that segmental and tandem duplication events under strong purifying selection are predominantly responsible for their convoluted structural divergences. Evidently, structural divergences were more prevalent in...Continue Reading

Citations

Mar 9, 2018·International Journal of Molecular Sciences·Wei LiDaigang Yang
Jul 15, 2020·Biophysics Reviews·Rhonda J Davey, Pierre Dj Moens
Jul 22, 2018·Biophysics Reviews·Joelle V F CoumansPierre D J Moens
Jan 5, 2021·Frontiers in Cell and Developmental Biology·Dhananjay K Pandey, Bhupendra Chaudhary
Aug 30, 2019·Current Opinion in Genetics & Development·Katrina B Velle, Lillian K Fritz-Laylin
May 8, 2021·Journal of Cell Science·Abigail AllenPartha Roy
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Kai MurkJuliane Schiweck

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