Oct 26, 2018

Evolutionary exploitation of PD-L1 expression in hormone receptor positive breast cancer

BioRxiv : the Preprint Server for Biology
Jeffrey WestMark Robertson-Tessi

Abstract

Based on clinical data from hormone positive breast cancer patients, we determined that there is a potential tradeoff between reducing tumor burden and altering metastatic potential when administering combination therapy of aromatase inhibitors and immune checkpoint inhibitors. While hormone-deprivation therapies serve to reduce tumor size in the neoadjuvant setting pre-surgery, they may induce tumors to change expression patterns towards a metastatic phenotype. We used mathematical modeling to explore how the timing of the therapies affects tumor burden and metastatic potential with an eye toward developing a dynamic prognostic score and reducing both tumor size and risk of metastasis.

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Mentioned in this Paper

Antiandrogen Therapy
Combination Drug Therapy
Aromatase Inhibitors
Neoplasms
Hormone Receptor
Tumor Burden
NR4A1 gene
Tumor Size
Programmed Cell Death Protein 1
Pharmacologic Substance

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