Evolutionary game theoretic strategy for optimal drug delivery to influence selection pressure in treatment of HIV-1

Journal of Mathematical Biology
Yu WuLijin Xia

Abstract

Cytotoxic T-lymphocyte (CTL) escape mutation is associated with long-term behaviors of human immunodeficiency virus type 1 (HIV-1). Recent studies indicate heterogeneous behaviors of reversible and conservative mutants while the selection pressure changes. The purpose of this study is to optimize the selection pressure to minimize the long-term virus load. The results can be used to assist in delivery of highly loaded cognate peptide-pulsed dendritic cells (DC) into lymph nodes that could change the selection pressure. This mechanism may be employed for controlled drug delivery. A mathematical model is proposed in this paper to describe the evolutionary dynamics involving viruses and T cells. We formulate the optimization problem into the framework of evolutionary game theory, and solve for the optimal control of the selection pressure as a neighborhood invader strategy. The strategy dynamics can be obtained to evolve the immune system to the best controlled state. The study may shed light on optimal design of HIV-1 therapy based on optimization of adaptive CTL immune response.

References

Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S P LayneM Dembo
Mar 1, 1993·Mathematical Biosciences·A S PerelsonR De Boer
Jun 8, 2002·Science·Sabine StollRonald N Germain
Jul 12, 2002·Nature·Andreas JungAndreas Meyerhans
Mar 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Douglas D RichmanChristos J Petropoulos
May 6, 2003·Nature Immunology·Philippe Bousso, Ellen Robey
Sep 10, 2003·Journal of Leukocyte Biology·Maureen M GoodenowJohn W Sleasman
Jan 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Que DangWei-Shau Hu
Jan 9, 2004·Nature·Thorsten R MempelUlrich H von Andrian
Feb 11, 2004·Nature Medicine·Alasdair LesliePhilip Goulder
Mar 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·David N LevyGeorge M Shaw
Jul 6, 2004·Mathematical Biosciences·David Wick, Steven G Self
Aug 7, 2004·Traffic·Clare Jolly, Quentin Sattentau
Nov 30, 2004·Nature Medicine·Wei LuJean-Marie Andrieu
Oct 10, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Arne TraulsenLorens A Imhof
Jul 31, 2007·Journal of Immune Based Therapies and Vaccines·Anders E Pedersen, Franca Ronchese
Oct 17, 2008·Nature Reviews. Microbiology·Quentin Sattentau
Jun 3, 2009·Evolution; International Journal of Organic Evolution·Dominik Wodarz, David N Levy
Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Judy DayLarry S Schlesinger
Feb 9, 2010·Mathematical Biosciences·Y U WuXiaopeng Zhao
Jul 20, 2010·Immunotherapy·Jean-Pierre Routy, Charles Nicolette

Citations

Oct 10, 2015·Computational and Mathematical Methods in Medicine·Gilberto González-Parra, Hana M Dobrovolny
Jun 29, 2013·Journal of Theoretical Biology·Marcel Joly, Darci Odloak
Jun 10, 2015·Journal of Biological Dynamics·Noah F Beggs, Hana M Dobrovolny

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