Evolutionary growth process of highly conserved sequences in vertebrate genomes

Gene
Minaka IshibashiTadashi Imanishi

Abstract

Genome sequence comparison between evolutionarily distant species revealed ultraconserved elements (UCEs) among mammals under strong purifying selection. Most of them were also conserved among vertebrates. Because they tend to be located in the flanking regions of developmental genes, they would have fundamental roles in creating vertebrate body plans. However, the evolutionary origin and selection mechanism of these UCEs remain unclear. Here we report that UCEs arose in primitive vertebrates, and gradually grew in vertebrate evolution. We searched for UCEs in two teleost fishes, Tetraodon nigroviridis and Oryzias latipes, and found 554 UCEs with 100% identity over 100 bps. Comparison of teleost and mammalian UCEs revealed 43 pairs of common, jawed-vertebrate UCEs (jUCE) with high sequence identities, ranging from 83.1% to 99.2%. Ten of them retain lower similarities to the Petromyzon marinus genome, and the substitution rates of four non-exonic jUCEs were reduced after the teleost-mammal divergence, suggesting that robust conservation had been acquired in the jawed vertebrate lineage. Our results indicate that prototypical UCEs originated before the divergence of jawed and jawless vertebrates and have been frozen as perfect co...Continue Reading

References

May 8, 2004·Science·Gill BejeranoDavid Haussler
Jun 25, 2004·Nucleic Acids Research·Kelly A FrazerInna Dubchak
Oct 6, 2006·Bioinformatics·S Blair HedgesSudhir Kumar
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daisuke KurokawaShinichi Aizawa
Dec 23, 2006·Science·Byrappa VenkateshSydney Brenner
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Aug 19, 2008·RNA Biology·Eirini BairaLin Zhang
Oct 4, 2008·Genome Research·Cory McLean, Gill Bejerano
Dec 20, 2008·Current Opinion in Genetics & Development·Vydianathan Ravi, Byrappa Venkatesh
Oct 23, 2009·Bioinformatics·Yoshihiro KawaharaTadashi Imanishi
Nov 26, 2009·Nucleic Acids Research·Chisato YamasakiTakashi Gojobori

❮ Previous
Next ❯

Citations

Jul 23, 2014·Nature Communications·Danielle C LynchFrancois P Bernier
Aug 8, 2018·Wiener medizinische Wochenschrift·Branko Velimirov, Carmen Ranftler
Jul 15, 2016·Genome Biology and Evolution·Jia-Xing YueLinda Z Holland
Dec 24, 2018·Developmental Biology·Luca AmbrosinoAnnamaria Locascio

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.