Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes

The Journal of Clinical Investigation
Ikram UllahJ Bergh

Abstract

Metastatic breast cancers are still incurable. Characterizing the evolutionary landscape of these cancers, including the role of metastatic axillary lymph nodes (ALNs) in seeding distant organ metastasis, can provide a rational basis for effective treatments. Here, we have described the genomic analyses of the primary tumors and metastatic lesions from 99 samples obtained from 20 patients with breast cancer. Our evolutionary analyses revealed diverse spreading and seeding patterns that govern tumor progression. Although linear evolution to successive metastatic sites was common, parallel evolution from the primary tumor to multiple distant sites was also evident. Metastatic spreading was frequently coupled with polyclonal seeding, in which multiple metastatic subclones originated from the primary tumor and/or other distant metastases. Synchronous ALN metastasis, a well-established prognosticator of breast cancer, was not involved in seeding the distant metastasis, suggesting a hematogenous route for cancer dissemination. Clonal evolution coincided frequently with emerging driver alterations and evolving mutational processes, notably an increase in apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like-associated (APOB...Continue Reading

References

Sep 19, 2018·Molecular and Cellular Biology·Daniel J SalamangoReuben S Harris
Jun 21, 2019·The Journal of Biological Chemistry·Jennifer L McCannReuben S Harris
Sep 15, 2019·Nature Communications·Patrick L LeslieChad V Pecot
Oct 17, 2019·Cold Spring Harbor Perspectives in Medicine·Hai WangXiang H-F Zhang
Dec 1, 2018·Breast Care·Florentia PeintingerCornelia Liedtke
Feb 10, 2019·Nature Communications·Jennifer L Caswell-JinChristina Curtis
May 9, 2020·Breast Cancer Research and Treatment·Luisa Edman KesslerAlexios Matikas
Jul 31, 2020·Breast Cancer Research : BCR·Madhurendra SinghGalina Selivanova
Apr 26, 2020·Cellular and Molecular Life Sciences : CMLS·Alexios-Fotios A MentisAthanasios G Papavassiliou
Aug 5, 2020·Nature Genetics·David Mas-Ponte, Fran Supek
Oct 10, 2020·Journal of Mammary Gland Biology and Neoplasia·Briana ToEran R Andrechek

Citations

Oct 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Hellman
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·B EfronS Holmes
Dec 7, 2002·Nature Genetics·Sridhar RamaswamyTodd R Golub
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Jan 22, 2004·Bioinformatics·Emmanuel ParadisKorbinian Strimmer
Mar 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marco ColleoniAron Goldhirsch
Jul 29, 2005·Nature·Andy J MinnJoan Massagué
Aug 2, 2005·Nature Reviews. Cancer·Britta WeigeltLaura van 't Veer
Dec 14, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·International Breast Cancer Study GroupAlan S Coates
Apr 22, 2006·Cell Cycle·Sunny Y Wong, Richard O Hynes
Jan 19, 2007·The New England Journal of Medicine·Rui LiuMichael F Clarke
Jul 6, 2010·Nucleic Acids Research·Kai WangHakon Hakonarson
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peter Van LooVessela N Kristensen
Nov 10, 2010·Breast Cancer Research : BCR·Alastair M ThompsonBreast Recurrence in Tissues Study Group
Feb 10, 2011·JAMA : the Journal of the American Medical Association·Armando E GiulianoMonica Morrow
Mar 15, 2011·Nature·Nicholas NavinMichael Wigler
Nov 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eitan AmirMark Clemons
Dec 27, 2011·Cancer Metastasis Reviews·Jutta EngelDieter Hölzel
Jan 20, 2012·Nature·Mel Greaves, Carlo C Maley
Jun 20, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Linda Sofie LindströmJ Bergh
Feb 12, 2013·Nature Biotechnology·Kristian CibulskisGad Getz
Mar 16, 2013·The Lancet Oncology·Viviana GalimbertiInternational Breast Cancer Study Group Trial 23-01 investigators
Apr 18, 2013·Cancer Metastasis Reviews·Edward J FoxLawrence A Loeb
Jun 8, 2013·Nature Medicine·Klaus PantelKornelia Polyak
Jul 16, 2013·Nature Genetics·Steven A RobertsDmitry A Gordenin
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Nov 28, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E KarlssonF Wärnberg
Mar 19, 2014·Nature Methods·Andrew RothSohrab P Shah
Jan 21, 2015·Nature Reviews. Clinical Oncology·Kamila Naxerova, Rakesh K Jain
Apr 2, 2015·Nature·Gunes GundemG Steven Bova
Jun 21, 2015·Cancer Discovery·Charles SwantonReuben S Harris
Jun 23, 2015·Nature Medicine·Lucy R YatesPeter J Campbell
Jul 15, 2015·Bioinformatics·Julian S GehringWolfgang Huber

Related Concepts

Patterns
Genome
Primary Neoplasm
Apolipoproteins B
Neoplasms
Cancer Progression
Growth Substances
Site
Genomics
Comparative Genomic Analysis

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Genomics

Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research here.