PMID: 9419229Mar 7, 1998Paper

Evolutionary history of the 11p15 human mucin gene family

Journal of Molecular Evolution
J L DesseynA Laine

Abstract

The four human mucin genes MUC6, MUC2, MUC5AC, and MUC5B are located at chromosome 11p15.5. It has been demonstrated that the three mucins MUC2, MUC5AC, and MUC5B contain several Cys-subdomains of 108 amino acid residues. In contrast, little information is available concerning MUC6. These Cys-subdomains contain 10 cysteine residues that have a highly conserved position. We present here a coherent probable evolutionary history of this human gene family after comparison of the nucleotide sequences of these Cys-subdomains. The three MUC loci MUC2, MUC5AC, and MUC5B may have evolved from a common ancestral gene by two successive duplications. Moreover, we can postulate that MUC5AC and MUC5B have evolved in a concerted manner, while MUC2 has evolved separately.

Citations

Oct 22, 2005·Digestive Diseases and Sciences·Su Youn NamIn Sung Song
Apr 15, 2004·Genomics·Karine RousseauNeil W Toribara
Mar 15, 2002·Trends in Biochemical Sciences·Jan DekkerAlexandra W C Einerhand
Nov 26, 2009·Nature Reviews. Cancer·Donald W Kufe
Feb 20, 1999·The Biochemical Journal·N MoniauxJ P Aubert
Dec 18, 2003·Hybridoma and Hybridomics·K RousseauD M Swallow
Feb 5, 2009·DNA and Cell Biology·Eun-Kyung AhnSun-Hee Leem
Sep 15, 2011·Journal of Gastroenterology and Hepatology·Yong H ShengMichael A McGuckin
Dec 1, 2011·Pathology International·Suguru YonezawaMasamichi Goto
Sep 14, 2007·Annual Review of Physiology·David J ThorntonMichael A McGuckin
Sep 9, 2006·American Journal of Respiratory Cell and Molecular Biology·Juan Perez-Vilar
Mar 10, 2012·American Journal of Respiratory Cell and Molecular Biology·Bradley W SchroederDavid J Erle
Nov 6, 2007·BMC Evolutionary Biology·Ryouka Kawahara, Mutsumi Nishida
May 22, 2008·Acta Histochemica Et Cytochemica·Kenichi HirabayashiRobert Yoshiyuki Osamura
May 16, 2002·Chest·George D LeikaufLeigh G Simpson
Jun 19, 2012·Clinical Epigenetics·Norishige YamadaSuguru Yonezawa
Apr 21, 2009·Molecular Phylogenetics and Evolution·Jean-Luc Desseyn
Nov 12, 2009·BioFactors·Satyanarayana RachaganiSurinder K Batra
Jul 2, 1999·Biophysical Journal·T J McMasterM J Miles
Aug 26, 2016·Scientific Reports·Duo XuOmer Gokcumen
Sep 9, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Cecilia SóñoraEduardo Osinaga
Nov 16, 2018·Annals of the American Thoracic Society·Jean-Luc DesseynValérie Gouyer
Dec 17, 2008·Mucosal Immunology·S K LindenM A McGuckin
Feb 13, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Karine RousseauDavid J Thornton
Jul 26, 2000·Molecular Biology and Evolution·J L DesseynA Laine
Mar 30, 2001·The Journal of Biological Chemistry·F SpadaE M Thompson
Jun 4, 2020·Cancer Metastasis Reviews·Koelina GangulySurinder K Batra
Dec 22, 2019·International Journal of Molecular Sciences·Xin MengHao Wu
Nov 20, 2019·Scientific Reports·Bastien DemouveauxJean-Luc Desseyn
Jul 4, 2018·Gastroenterology Research and Practice·Chao LiLei Wang
Oct 29, 1998·Biochemical and Biophysical Research Communications·G D OffnerR F Troxler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.