Nov 6, 2015

Evolutionary history of the global emergence of the Escherichia coli epidemic clone ST131

BioRxiv : the Preprint Server for Biology
Nicole Stoesser

Abstract

ABSTRACT Background Escherichia coli sequence type 131 (ST131) has emerged globally as the most predominant lineage within this clinically important species, and its association with fluoroquinolone and extended-spectrum cephalosporin resistance impacts significantly on treatment. The evolutionary histories of this lineage, and of important antimicrobial resistance elements within it, remain unclearly defined. Results This study of the largest worldwide collection (n = 215) of sequenced ST131 E. coli isolates to date demonstrates that clonal expansion of two previously recognized antimicrobial-resistant clades, C1/H30R and C2/H30Rx, started around 25 years ago, consistent with the widespread introduction of fluoroquinolones and extended-spectrum cephalosporins in clinical medicine. These two clades appear to have emerged in the United States, with the expansion of the C2/H30Rx clade driven by the acquisition of a blaCTX-M-15-containing IncFII-like plasmid that has subsequently undergone extensive rearrangement. Several other evolutionary processes influencing the trajectory of this drug-resistant lineage are described, including sporadic acquisitions of CTX-M resistance plasmids, and chromosomal integration of blaCTX-M within s...Continue Reading

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Mentioned in this Paper

Study
Fluoroquinolone antiinfectives, ophthalmologic
M15 protein
Fluoroquinolones
Fluoroquinolone antibacterials, systemic
Genes
Clinical Medicine
Cephalosporins
Clone
Cell Growth

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