Evolutionary History of the Photolyase/Cryptochrome Superfamily in Eukaryotes

PloS One
Qiming Mei, Volodymyr Dvornyk

Abstract

Photolyases and cryptochromes are evolutionarily related flavoproteins, which however perform distinct physiological functions. Photolyases (PHR) are evolutionarily ancient enzymes. They are activated by light and repair DNA damage caused by UV radiation. Although cryptochromes share structural similarity with DNA photolyases, they lack DNA repair activity. Cryptochrome (CRY) is one of the key elements of the circadian system in animals. In plants, CRY acts as a blue light receptor to entrain circadian rhythms, and mediates a variety of light responses, such as the regulation of flowering and seedling growth. We performed a comprehensive evolutionary analysis of the CRY/PHR superfamily. The superfamily consists of 7 major subfamilies: CPD class I and CPD class II photolyases, (6-4) photolyases, CRY-DASH, plant PHR2, plant CRY and animal CRY. Although the whole superfamily evolved primarily under strong purifying selection (average ω = 0.0168), some subfamilies did experience strong episodic positive selection during their evolution. Photolyases were lost in higher animals that suggests natural selection apparently became weaker in the late stage of evolutionary history. The evolutionary time estimates suggested that plant and a...Continue Reading

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Citations

Jun 3, 2016·Integrative and Comparative Biology·Megan L Porter
Nov 1, 2016·Photochemistry and Photobiology·Wentao Li, Shisheng Li
Dec 22, 2016·Cellular and Molecular Life Sciences : CMLS·Claudia P Spampinato
Feb 15, 2018·Photochemistry and Photobiology·Lars Olof Björn
Sep 27, 2018·Photochemistry and Photobiology·Rajiv Kumar KarIgor Schapiro
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Nov 20, 2016·Photochemistry and Photobiology·Aba Losi, Wolfgang Gärtner
Jul 15, 2020·Biological Chemistry·Stephan KiontkeAlfred Batschauer
Nov 13, 2019·Parasites & Vectors·Maria Beatriz S MotaRafael D Mesquita
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Nov 28, 2020·Planta·Durga Prasad Biswal, Kishore Chandra Sekhar Panigrahi
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Software Mentioned

TBLASTN
PhyML
REL
jModelTest
BLASTP
HyPhy
PAML
BEAST
DIVERGE
ConSurf

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