Evolutionary implications of non-neutral mitochondrial genetic variation

Trends in Ecology & Evolution
Damian K DowlingJohan Lindell

Abstract

Sequence variation in mitochondrial DNA (mtDNA) was traditionally considered to be selectively neutral. However, an accumulating body of evidence indicates that this assumption is invalid. Furthermore, recent advances indicate that mtDNA polymorphism can be maintained within populations via selection on the joint mitochondrial-nuclear genotype. Here, we review the latest findings that show mitochondrial and cytoplasmic genetic variation for life-history traits and fitness. We highlight the key importance of the mitochondrial-nuclear interaction as a unit of selection and discuss the consequences of mitochondrially encoded fitness effects on several key evolutionary processes. Our goal is to draw attention to the profound, yet neglected, influence of the mitochondrial genome on the fields of ecology and evolution.

Citations

May 28, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Duur K AanenMadeleine Beekman
May 28, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Madeleine BeekmanDuur K Aanen
May 28, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jonci N WolffDamian K Dowling
Jun 3, 2014·BMC Genomics·Björn RogellDamian K Dowling
Apr 4, 2014·Genome Biology and Evolution·José Melo-FerreiraPaulo C Alves
Aug 22, 2014·Proceedings. Biological Sciences·Gonçalo SilvaRita Castilho
Oct 17, 2014·Proceedings. Biological Sciences·Hanne LøvlieGöran Arnqvist
May 5, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jochen B W WolfNiclas Backström
Oct 13, 2011·BMC Evolutionary Biology·Andreas HapkeOliver Zupke
Dec 19, 2008·Parasitology·P NejsumS M Thamsborg
Jan 5, 2012·Human Reproduction·Jim A MossmanAllan A Pacey
May 27, 2010·Theory in Biosciences = Theorie in Den Biowissenschaften·Filipe O Costa, Gary R Carvalho
Dec 14, 2011·Proceedings. Biological Sciences·Zena HadjivasiliouNick Lane
Aug 2, 2013·Proceedings. Biological Sciences·Felipe S Barreto, Ronald S Burton
Aug 16, 2013·Proceedings. Biological Sciences·Geoffrey E Hill, James D Johnson
Aug 21, 2014·The American Naturalist·Simon R EvansArild Husby
Apr 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Steve J PerlmanBrent E Gowen
Sep 30, 2015·Molecular Biology and Evolution·Jeffrey R AdrionKristi L Montooth
Apr 19, 2016·Evolutionary Applications·Anna QvarnströmPäivi M Sirkiä
Oct 1, 2015·Evolution; International Journal of Organic Evolution·Winston K W YeeDamian K Dowling
Jan 3, 2012·Molecular Phylogenetics and Evolution·David J CerasaleIrby J Lovette

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