Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes

Nucleic Acids Research
Nhan van TranMarc Graille

Abstract

Protein synthesis is a complex and highly coordinated process requiring many different protein factors as well as various types of nucleic acids. All translation machinery components require multiple maturation events to be functional. These include post-transcriptional and post-translational modification steps and methylations are the most frequent among these events. In eukaryotes, Trm112, a small protein (COG2835) conserved in all three domains of life, interacts and activates four methyltransferases (Bud23, Trm9, Trm11 and Mtq2) that target different components of the translation machinery (rRNA, tRNAs, release factors). To clarify the function of Trm112 in archaea, we have characterized functionally and structurally its interaction network using Haloferax volcanii as model system. This led us to unravel that methyltransferases are also privileged Trm112 partners in archaea and that this Trm112 network is much more complex than anticipated from eukaryotic studies. Interestingly, among the identified enzymes, some are functionally orthologous to eukaryotic Trm112 partners, emphasizing again the similarity between eukaryotic and archaeal translation machineries. Other partners display some similarities with bacterial methyltr...Continue Reading

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Citations

Feb 13, 2019·Journal of Bacteriology·Ningxi YuPatrick A Limbach
Jul 23, 2019·Nucleic Acids Research·Nhan van TranDenis L J Lafontaine
Dec 20, 2018·International Journal of Molecular Sciences·Chie Tomikawa
May 27, 2020·Nucleic Acids Research·Clayton B WoodcockXiaodong Cheng
Apr 3, 2020·Current Genetics·Rościsław KrutyhołowaSebastian Glatt
Apr 18, 2020·Wiley Interdisciplinary Reviews. RNA·Phillip J McCownJessica A Brown
Mar 28, 2019·Nucleic Acids Research·Rościsław KrutyhołowaSebastian Glatt
Sep 25, 2020·The Biochemical Journal·Jie GaoZhongliang Zhu
Nov 7, 2020·International Journal of Molecular Sciences·Nour-El-Hana AbbassiTing-Yu Lin
May 24, 2021·Nucleic Acids Research·Stephanie OerumCarine Tisné

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Datasets Mentioned

BETA
PXD008466

Methods Mentioned

BETA
co-immunoprecipitation
PCR
X-ray
co-IP
size-exclusion chromatographies

Software Mentioned

PHENIX
RESOLVE
EP
PHASER
COOT
Consurf
BUSTER
SHELXD

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