Evolutionary origin and divergence of PQRFamide peptides and LPXRFamide peptides in the RFamide peptide family. Insights from novel lamprey RFamide peptides

The FEBS Journal
Tomohiro OsugiKazuyoshi Tsutsui

Abstract

Among the RFamide peptide groups, PQRFamide peptides, such as neuropeptide FF (NPFF) and neuropeptide AF (NPAF), share a common C-terminal Pro-Gln-Arg-Phe-NH(2) motif. LPXRFamide (X = L or Q) peptides, such as gonadotropin-inhibitory hormone (GnIH), frog growth hormone-releasing peptide (fGRP), goldfish LPXRFamide peptide and mammalian RFamide-related peptides (RFRPs), also share a C-terminal Leu-Pro-Leu/Gln-Arg-Phe-NH(2) motif. Such a similar C-terminal structure suggests that these two groups may have diverged from a common ancestral gene. In this study, we sought to clarify the evolutionary origin and divergence of these two groups, by identifying novel RFamide peptides from the brain of sea lamprey, one of only two extant groups of the oldest lineage of vertebrates, Agnatha. A novel lamprey RFamide peptide was identified by immunoaffinity purification using the antiserum against LPXRFamide peptide. The lamprey RFamide peptide did not contain a C-terminal LPXRFamide motif, but had the sequence SWGAPAEKFWMRAMPQRFamide (lamprey PQRFa). A cDNA of the precursor encoded one lamprey PQRFa and two related peptides. These related peptides, which also had the C-terminal PQRFamide motif, were further identified as mature endogenous li...Continue Reading

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Citations

Jul 11, 2012·The Journal of Biological Chemistry·Daniel RathmannAnnette G Beck-Sickinger
May 15, 2008·Proceedings. Biological Sciences·Timothy J GreivesGregory E Demas
Jul 23, 2014·Brain Research Bulletin·Anita KovácsLászló Lénárd
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Jul 3, 2015·General and Comparative Endocrinology·Tomohiro OsugiKazuyoshi Tsutsui
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Sep 2, 2014·Frontiers in Neuroscience·Tomohiro OsugiKazuyoshi Tsutsui
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Jan 14, 2017·Frontiers in Endocrinology·Kazuyoshi Tsutsui, Takayoshi Ubuka
Nov 30, 2018·Frontiers in Endocrinology·Kazuyoshi Tsutsui, Takayoshi Ubuka
Nov 9, 2018·Frontiers in Neuroscience·Takayoshi Ubuka, Kazuyoshi Tsutsui
Jan 16, 2021·Frontiers in Neuroendocrinology·Kazuyoshi Tsutsui, Takayoshi Ubuka

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