Evolutionary origins of Hsp90 chaperones and a deep paralogy in their bacterial ancestors

The Journal of Eukaryotic Microbiology
Alexandra Stechmann, Thomas Cavalier-Smith

Abstract

The 82-90 kD family of molecular chaperone proteins has homologs in eukaryotes (Hsp90) and many eubacteria (HtpG) but not in Archaebacteria. We used representatives of all four different eukaryotic paralogs (cytosolic, endoplasmic reticulum (ER), chloroplast, mitochondrial) together with numerous eubacterial HtpG proteins for phylogenetic analyses to investigate their evolutionary origins. Our trees confirm that none of the organellar Hsp90s derives from the endosymbionts of early eukaryotes. Contrary to previous suggestions of distant origins through lateral gene transfer (LGT) all eukaryote Hsp90s are related to Gram-positive eubacterial HtpG proteins. The nucleocytosolic, ER and chloroplast Hsp90 paralogs are clearly mutually related. The origin of mitochondrial Hsp90 is more obscure, as these sequences are deeply nested within eubacteria. Our trees also reveal a deep split within eubacteria into a group of mainly long-branching sequences (including the eukaryote mitochondrial Hsp90s) and another group comprising exclusively short-branching HtpG proteins, from which the cytosolic/ER versions probably arose. Both versions are present in several eubacterial phyla, suggesting gene duplication very early in eubacterial evolution...Continue Reading

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Citations

Mar 28, 2008·Plant Molecular Biology·Constantinos PrassinosPolydefkis Hatzopoulos
Nov 8, 2006·Infection and Immunity·Sherry A ColemanRobert A Heinzen
Jul 23, 2013·PLoS Genetics·Maximilian O PressElhanan Borenstein
Feb 9, 2012·Science China. Life Sciences·Zhaoqing ZengZhihe Yu
Mar 27, 2009·Molecular and Biochemical Parasitology·Diana WiderDidier Picard
Jul 3, 2013·Journal of Proteomics·Perinur BozaykutBetul Karademir
Oct 20, 2011·Biochimica Et Biophysica Acta·Jill L Johnson
Dec 14, 2018·F1000Research·Oyeyemi O AjayiIkhide G Imumorin
Jun 28, 2017·Journal of Biomolecular NMR·Kari PedersonJames H Prestegard
May 9, 2021·Cryobiology·José Carlos Ferreira-SilvaMarcos Antonio Lemos Oliveira
Nov 1, 2021·FEMS Yeast Research·Julia L Crunden, Stephanie Diezmann

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Software Mentioned

- Puzzle
Phylip
BIONJ
Clustal X
protdist
ProML
Puzzle
GDE
MP
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