Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic.

Nature Microbiology
Maciej F BoniDavid L Robertson


There are outstanding evolutionary questions on the recent emergence of human coronavirus SARS-CoV-2 including the role of reservoir species, the role of recombination and its time of divergence from animal viruses. We find that the sarbecoviruses-the viral subgenus containing SARS-CoV and SARS-CoV-2-undergo frequent recombination and exhibit spatially structured genetic diversity on a regional scale in China. SARS-CoV-2 itself is not a recombinant of any sarbecoviruses detected to date, and its receptor-binding motif, important for specificity to human ACE2 receptors, appears to be an ancestral trait shared with bat viruses and not one acquired recently via recombination. To employ phylogenetic dating methods, recombinant regions of a 68-genome sarbecovirus alignment were removed with three independent methods. Bayesian evolutionary rate and divergence date estimates were shown to be consistent for these three approaches and for two different prior specifications of evolutionary rates based on HCoV-OC43 and MERS-CoV. Divergence dates between SARS-CoV-2 and the bat sarbecovirus reservoir were estimated as 1948 (95% highest posterior density (HPD): 1879-1999), 1969 (95% HPD: 1930-2000) and 1982 (95% HPD: 1948-2009), indicating t...Continue Reading


Mar 1, 1992·Microbiological Reviews·R G WebsterY Kawaoka
Oct 6, 2000·Molecular Biology and Evolution·M H Schierup, J Hein
Nov 14, 2002·Annual Review of Genetics·David PosadaEdward C Holmes
Dec 9, 2003·Molecular Biology and Evolution·David Bryant, Vincent Moulton
Jul 5, 2006·Molecular Biology and Evolution·Sergei L Kosakovsky PondSimon D W Frost
Mar 21, 2008·Journal of Virology·Maciej F BoniEdward C Holmes
Apr 21, 2009·Methods in Molecular Biology·Kazutaka KatohHiroyuki Toh
Mar 29, 2013·Journal of Virology·John-Sebastian EdenPeter A White
May 23, 2014·Proceedings. Biological Sciences·Sebastián DuchêneSimon Y W Ho
Nov 6, 2014·Molecular Biology and Evolution·Lam-Tung NguyenBui Quang Minh
Apr 22, 2015·Methods in Ecology and Evolution·Olga ChernomorArndt von Haeseler
Nov 10, 2015·Nature Medicine·Vineet D MenacheryRalph S Baric
Mar 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Vineet D MenacheryRalph S Baric
Mar 26, 2016·Trends in Microbiology·Shuo SuGeorge F Gao
Jun 3, 2016·Journal of Virology·Pakorn Aiewsakun, Aris Katzourakis
Oct 14, 2016·Nature·Edward C HolmesKristian G Andersen
Oct 25, 2016·Trends in Microbiology·Diego ForniManuela Sironi
May 26, 2015·Virus Evolution·Darren P MartinBrejnev Muhire
Oct 25, 2016·Virus Evolution·Nídia Sequeira TrovãoPhilippe Lemey
Apr 7, 2017·Virology·Xian-Dan LinYong-Zhen Zhang
Oct 14, 2017·Molecular Biology and Evolution·Ha Minh LamMaciej F Boni
Jan 18, 2018·ELife·Gytis DudasTrevor Bedford
Jun 9, 2018·Nature·Edward C HolmesKristian G Andersen
Jun 27, 2018·Virus Evolution·Marc A SuchardAndrew Rambaut
Feb 23, 2019·Viruses·Antonio C P WongPatrick C Y Woo
Apr 21, 2019·Molecular Biology and Evolution·Jade Vincent MembrebePhilippe Lemey
Jan 23, 2020·Journal of Medical Virology·Wei JiXingguang Li
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Mar 4, 2020·Nature Microbiology·UNKNOWN Coronaviridae Study Group of the International Committee on Taxonomy of Viruses
Mar 11, 2020·Lancet·Yuntao WuZhi-Ming Zheng
Mar 29, 2020·Nature·Tommy Tsan-Yuk LamWu-Chun Cao

❮ Previous
Next ❯


Sep 3, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Theodore G Schurr
Sep 9, 2020·The Indian Journal of Medical Research·Priya AbrahamVarsha Potdar
Sep 4, 2020·Genome Research·Alberto Gómez-CarballaAntonio Salas
Aug 21, 2020·Nature Ecology & Evolution
Sep 23, 2020·Animals : an Open Access Journal From MDPI·Judith RechtMarcelo R Sánchez-Villagra
Sep 23, 2020·Nature Reviews. Microbiology·Russell Y NechesNikos C Kyrpides
Sep 30, 2020·Scandinavian Journal of Immunology·Donald Bellgrau, Jaime F Modiano
Oct 9, 2020·Infectious Diseases of Poverty·Jakob ZinsstagXiao-Nong Zhou
Oct 13, 2020·Frontiers in Microbiology·Yuki Furuse, Hitoshi Oshitani
Oct 18, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Horllys Gomes BarretoVagner Augusto Benedito
Oct 31, 2020·Wiener klinische Wochenschrift·Franz X Heinz, Karin Stiasny
Dec 2, 2020·Emerging Topics in Life Sciences·Ny Anjara Fifi RavelomanantsoaCara E Brook
Dec 4, 2020·Emerging Topics in Life Sciences·Sumana Sanyal
Dec 7, 2020·Briefings in Bioinformatics·Matteo ChiaraGraziano Pesole
Nov 25, 2020·Basic & Clinical Pharmacology & Toxicology·Valeria CagnoYoussef Daali
Nov 5, 2020·Molecular Biology and Evolution·Yiyan YangXiaofang Jiang
Aug 14, 2020·The Journal of Cell Biology·Fred D MastJohn D Aitchison
Dec 19, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kefang LiuGeorge Fu Gao
Dec 10, 2020·Molecular Biology and Evolution·Lenore PipesRasmus Nielsen
Dec 30, 2020·Expert Review of Anti-infective Therapy·Seyed MohammadReza HashemianAli Akbar Velayati
Jan 6, 2021·Journal of Applied Genetics·Szymon HryhorowiczEwa Ziętkiewicz
Nov 12, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·For Yue TsoCharles Wood
Dec 29, 2020·Computational and Structural Biotechnology Journal·Christos A Ouzounis
Jan 9, 2021·Briefings in Bioinformatics·Tao HuWeifeng Shi
Aug 28, 2020·Cell·David M Morens, Anthony S Fauci
Jan 14, 2021·Journal of Molecular Evolution·David Posada, Keith A Crandall
Jan 14, 2021·International Reviews of Immunology·Manali DattaAfsar R Naqvi
Dec 29, 2020·Biomaterials·David WibowoBernd H A Rehm
Dec 10, 2020·Transboundary and Emerging Diseases·Jeffrey S HallErik Hofmeister
Jan 19, 2021·Journal of Basic Microbiology·Swapnil B KadamVitthal T Barvkar
Jan 20, 2021·Veterinary Research Communications·Beatriz do ValeAna Cláudia Coelho
Jan 22, 2021·Xenotransplantation·Tanja Opriessnig, Yao-Wei Huang
Nov 14, 2020·EBioMedicine·Ramon Lorenzo-RedondoEgon A Ozer
Feb 4, 2021·Genetics and Molecular Biology·Joel Henrique EllwangerJosé Artur Bogo Chies
Feb 5, 2021·Journal of Immunoassay & Immunochemistry·Marinela BostanCoralia Bleotu
Dec 18, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yuki Furuse
Dec 1, 2020·Acta Tropica·Sanjay Kumar Mishra, Timir Tripathi
Jan 2, 2021·Trends in Ecology & Evolution·Arinjay BanerjeeAaron T Irving
Feb 10, 2021·Der Pathologe·Maximilian AckermannDanny D Jonigk

❮ Previous
Next ❯

Software Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BioRxiv : the Preprint Server for Biology
R. Iruegas LopezIngo Ebersberger
BioRxiv : the Preprint Server for Biology
S. LytrasDavid L Robertson
© 2021 Meta ULC. All rights reserved