Evolutionary pattern of the FAE1 gene in brassicaceae and its correlation with the erucic acid trait

PloS One
Xiaoqin SunYueyu Hang

Abstract

The fatty acid elongase 1 (FAE1) gene catalyzes the initial condensation step in the elongation pathway of VLCFA (very long chain fatty acid) biosynthesis and is thus a key gene in erucic acid biosynthesis. Based on a worldwide collection of 62 accessions representing 14 tribes, 31 genera, 51 species, 4 subspecies and 7 varieties, we conducted a phylogenetic reconstruction and correlation analysis between genetic variations in the FAE1 gene and the erucic acid trait, attempting to gain insight into the evolutionary patterns and the correlations between genetic variations in FAE1 and trait variations. The five clear, deeply diverged clades detected in the phylogenetic reconstruction are largely congruent with a previous multiple gene-derived phylogeny. The Ka/Ks ratio (<1) and overall low level of nucleotide diversity in the FAE1 gene suggest that purifying selection is the major evolutionary force acting on this gene. Sequence variations in FAE1 show a strong correlation with the content of erucic acid in seeds, suggesting a causal link between the two. Furthermore, we detected 16 mutations that were fixed between the low and high phenotypes of the FAE1 gene, which constitute candidate active sites in this gene for altering the...Continue Reading

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Citations

Mar 14, 2018·American Journal of Botany·Anushree SanyalGuillaume Decocq
Sep 11, 2016·BMC Evolutionary Biology·Anushree Sanyal, Guillaume Decocq

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Datasets Mentioned

BETA
U29142.1
KF030541
KF030557
KF030546
AY888037.1
AY888043.1
AY888044.1
KF030553
KF030554
AY082610

Methods Mentioned

BETA
PCR

Software Mentioned

Sequencer
DnaSp
MEGA
MEME
jModeltest
GeneCodes
MrBayes
OLIGO

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