Evolutionary processes in populations of Cryptosporidium inferred from gp60 sequence data

Parasitology Research
Juan C Garcia-R, David T S Hayman

Abstract

Cryptosporidiosis is one of the most common human infectious diseases globally. The gp60 gene has been adopted as a key marker for molecular epidemiological investigations into this protozoan disease because of the capability to characterize genotypes and detect variants within Cryptosporidium species infecting humans. However, we know relatively little about the potential spatial and temporal variation in population demography that can be inferred from this gene beyond that it is recognized to be under selective pressure. Here, we analyzed the genetic variation in time and space within two putative populations of Cryptosporidium in New Zealand to infer the processes behind the patterns of sequence polymorphism. Analyses using Tajima's D, Fu, and Li's D* and F* tests show significant departures from neutrality in some populations and indicate the selective maintenance of alleles within some populations. Demographic analyses showed distortions in the pattern of the genetic variability caused by high recombination rates and population expansion, which was observed in case notification data. Our results showed that processes acting on populations that have similar effects can be distinguished from one another and multiple processe...Continue Reading

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Citations

Aug 11, 2020·Parasitology·Juan C Garcia-RDavid T S Hayman
Jun 5, 2020·Parasitology Research·Juan C Garcia-RDavid T S Hayman
Sep 3, 2021·Food and Waterborne Parasitology·Jennifer K O'LearyBrigid Lucey

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Methods Mentioned

BETA
PCR

Software Mentioned

DnaSP
MUSCLE merger
SplitsTree
MAFFT aligner
MEGA
Geneious

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